DegronMD

Uniprot ID: Q96I76

Source protein: G patch domain-containing protein 3

Source gene: GPATCH3

Class: DEG_APCC_DBOX_1

Location: 470:478

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8519

ASA_SCORE: 75.5889

COIL: 0.6916

CONS_SCORE: 0.4991

DSS_SCORE: 0.4727

HELIX: 0.021

FCONS_SCORE: 0.8799

RIG_SCORE: 0.6996

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P484H	TCGA-B5-A3FC	UCEC	TCGA	RRNGLGLIS	DEG_APCC_DBOX_1	0.1667
p.P484H	DO41871	UCEC	ICGC	RRNGLGLIS	DEG_APCC_DBOX_1	0.1667
p.F463C	TCGA-BR-8680	STAD	TCGA	RRNGLGLIS	DEG_APCC_DBOX_1	0.1389
p.F463C	DO47769	STAD	ICGC	RRNGLGLIS	DEG_APCC_DBOX_1	0.1389
p.R471I	TCGA-DK-A6AW	BLCA	TCGA	RRNGLGLIS	DEG_APCC_DBOX_1	0.8102
p.R471I	DO48566	BLCA	ICGC	RRNGLGLIS	DEG_APCC_DBOX_1	0.8102
p.G464W	TCGA-DU-6392	LGG	TCGA	RRNGLGLIS	DEG_APCC_DBOX_1	0.1667
p.G464W	DO22237	LGG	ICGC	RRNGLGLIS	DEG_APCC_DBOX_1	0.1667
p.L474F	TCGA-ER-A2NF	SKCM	TCGA	RRNGLGLIS	DEG_APCC_DBOX_1	0.6981
p.L474F	DO47451	SKCM	ICGC	RRNGLGLIS	DEG_APCC_DBOX_1	0.6981
p.Y481H	DO229240	THCA	ICGC	RRNGLGLIS	DEG_APCC_DBOX_1	0.25
p.D488Y	SIDM00193	Colorectal Carcinoma	GDSC	RRNGLGLIS	DEG_APCC_DBOX_1	0.0556
p.D488Y	ACH-000991	Colon/Colorectal Cancer	CCLE	RRNGLGLIS	DEG_APCC_DBOX_1	0.0556
p.D488Y	SNU-81	large_intestine	COSMIC	RRNGLGLIS	DEG_APCC_DBOX_1	0.0556
p.E483K	SIDM01618	B-Lymphoblastic Leukemia	GDSC	RRNGLGLIS	DEG_APCC_DBOX_1	0.1944
p.E483K	ACH-000942	Leukemia	CCLE	RRNGLGLIS	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96I76	G patch domain-containing protein 3	DEG_APCC_DBOX_1	470:478	RRNGLGLIS	APC,CDC20,FZR1	0.8519	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons