DegronMD - Q96ID5(IGSF21)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R210M	TCGA-44-8120	LUAD	TCGA	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation rewiring degron network	0.25
p.R210M	TCGA-96-7544	LUSC	TCGA	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation rewiring degron network	0.25
p.R210M	DO45402	LUAD	ICGC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation rewiring degron network	0.25
p.R210M	DO26425	LUSC	ICGC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation rewiring degron network	0.25
p.S209R	TCGA-86-8358	LUAD	TCGA	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation blocking phosphorylation signal	0.6667
p.S209R	DO25471	LUAD	ICGC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation blocking phosphorylation signal	0.6667
p.R213C	TCGA-A5-A0G2	UCEC	TCGA	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation altering degron motif	0.8301
p.R213C	DO41235	UCEC	ICGC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation altering degron motif	0.8301
p.R213H	TCGA-AP-A0LM	UCEC	TCGA	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation altering degron motif	0.8244
p.R213H	DO233260	GACA	ICGC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation altering degron motif	0.8244
p.R213H	DO43306	UCEC	ICGC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation altering degron motif	0.8244
p.R213H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation altering degron motif	0.8244
p.R213H	ACH-001127	Leukemia	CCLE	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation altering degron motif	0.8244
p.R213H	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation altering degron motif	0.8244
p.T223P	TCGA-CV-5435	HNSC	TCGA	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation rewiring degron network	0.2222
p.T223P	DO14299	HNSC	ICGC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation rewiring degron network	0.2222
p.G204S	TCGA-EE-A3J7	SKCM	TCGA	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation rewiring degron network	0.0833
p.G204S	DO48770	SKCM	ICGC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation rewiring degron network	0.0833
p.K224E	TCGA-EY-A1GK	UCEC	TCGA	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation substituting flanking lysine	0.3056
p.K224E	DO42985	UCEC	ICGC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation substituting flanking lysine	0.3056
p.R218H	DO222617	BTCA	ICGC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation altering degron motif	0.7133
p.S214G	DO227844	COCA	ICGC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation altering degron motif	0.5882
p.K227N	DO229018	LICA	ICGC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation substituting flanking lysine	0.2222
p.D219Y	DO229029	LICA	ICGC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation altering degron motif	0.7325
p.R213L	DO229037	LICA	ICGC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation altering degron motif	0.8428
p.D221N	DO222868	MELA	ICGC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation rewiring degron network	0.2778
p.R218C	SIDM01217	Other Blood Cancers	GDSC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation altering degron motif	0.719
p.R218C	SIDM00220	Ovarian Carcinoma	GDSC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation altering degron motif	0.719
p.R218C	ACH-000962	Ovarian Cancer	CCLE	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation altering degron motif	0.719
p.R218C	ACH-001145	Ovarian Cancer	CCLE	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation altering degron motif	0.719
p.R218C	ACH-001431	Bone Cancer	CCLE	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation altering degron motif	0.719
p.R218C	OC-314	ovary	COSMIC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation altering degron motif	0.719
p.R218C	MY-M12	haematopoietic and lymphoid tissue	COSMIC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation altering degron motif	0.719
p.D222N	SIDM00224	Mesothelioma	GDSC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation rewiring degron network	0.25
p.D222N	ACH-000569	Lung Cancer	CCLE	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation rewiring degron network	0.25
p.D222N	IST-MES1	pleura	COSMIC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	213:219	Mutation rewiring degron network	0.25

Kaplan plot for IGSF21 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IGSF21

UniProt ID: Q96ID5

Entrez ID: 84966

Protein name: Immunoglobulin superfamily member 21 (IgSF21)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IGSF21 in