DegronMD

Uniprot ID: Q96ID5

Source protein: Immunoglobulin superfamily member 21

Source gene: IGSF21

Class: LIG_APCC_ABBAyCdc20_2

Location: 213:219

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8513

ASA_SCORE: 65.6857

COIL: 0.4247

CONS_SCORE: 0.5682

DSS_SCORE: 0.5793

HELIX: 0.0366

FCONS_SCORE: 1.0632

RIG_SCORE: 0.7248

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R210M	TCGA-44-8120	LUAD	TCGA	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.25
p.R210M	TCGA-96-7544	LUSC	TCGA	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.25
p.R210M	DO45402	LUAD	ICGC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.25
p.R210M	DO26425	LUSC	ICGC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.25
p.S209R	TCGA-86-8358	LUAD	TCGA	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.6667
p.S209R	DO25471	LUAD	ICGC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.6667
p.R213C	TCGA-A5-A0G2	UCEC	TCGA	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.8301
p.R213C	DO41235	UCEC	ICGC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.8301
p.R213H	TCGA-AP-A0LM	UCEC	TCGA	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.8244
p.R213H	DO233260	GACA	ICGC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.8244
p.R213H	DO43306	UCEC	ICGC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.8244
p.R213H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.8244
p.R213H	ACH-001127	Leukemia	CCLE	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.8244
p.R213H	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.8244
p.T223P	TCGA-CV-5435	HNSC	TCGA	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.2222
p.T223P	DO14299	HNSC	ICGC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.2222
p.G204S	TCGA-EE-A3J7	SKCM	TCGA	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.0833
p.G204S	DO48770	SKCM	ICGC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.0833
p.K224E	TCGA-EY-A1GK	UCEC	TCGA	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.3056
p.K224E	DO42985	UCEC	ICGC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R218H	DO222617	BTCA	ICGC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.7133
p.S214G	DO227844	COCA	ICGC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.5882
p.K227N	DO229018	LICA	ICGC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.2222
p.D219Y	DO229029	LICA	ICGC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.7325
p.R213L	DO229037	LICA	ICGC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.8428
p.D221N	DO222868	MELA	ICGC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R218C	SIDM01217	Other Blood Cancers	GDSC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.719
p.R218C	SIDM00220	Ovarian Carcinoma	GDSC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.719
p.R218C	ACH-000962	Ovarian Cancer	CCLE	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.719
p.R218C	ACH-001145	Ovarian Cancer	CCLE	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.719
p.R218C	ACH-001431	Bone Cancer	CCLE	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.719
p.R218C	OC-314	ovary	COSMIC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.719
p.R218C	MY-M12	haematopoietic_and_lymphoid_tissue	COSMIC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.719
p.D222N	SIDM00224	Mesothelioma	GDSC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.25
p.D222N	ACH-000569	Lung Cancer	CCLE	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.25
p.D222N	IST-MES1	pleura	COSMIC	RSLLHRD	LIG_APCC_ABBAyCdc20_2	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RSLLHRD

Degron related mutations and impact score

Drug responses associated with IGSF21 mutations

All proteins holding degron of RSLLHRD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96ID5	Immunoglobulin superfamily member 21	LIG_APCC_ABBAyCdc20_2	213:219	RSLLHRD	APC,CDC20,FZR1	0.8513	More...