DegronMD - Q96II8(LRCH3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R322I	TCGA-A5-A1OF	UCEC	TCGA	DSGFNS	DEG_SCF_TRCP1_1	310:315	Mutation rewiring degron network	0.1389
p.R322I	DO42568	UCEC	ICGC	DSGFNS	DEG_SCF_TRCP1_1	310:315	Mutation rewiring degron network	0.1389
p.N314S	TCGA-CW-5580	KIRC	TCGA	DSGFNS	DEG_SCF_TRCP1_1	310:315	Mutation altering degron motif	0.5958
p.N314S	DO19208	KIRC	ICGC	DSGFNS	DEG_SCF_TRCP1_1	310:315	Mutation altering degron motif	0.5958
p.L309V	DO52605	BOCA	ICGC	DSGFNS	DEG_SCF_TRCP1_1	310:315	Mutation rewiring degron network	0.3056
p.N319K	DO51634	CESC	ICGC	DSGFNS	DEG_SCF_TRCP1_1	310:315	Mutation rewiring degron network	0.2222
p.F320V	DO6308	CESC	ICGC	DSGFNS	DEG_SCF_TRCP1_1	310:315	Mutation rewiring degron network	0.1944
p.A308S	DO229028	LICA	ICGC	DSGFNS	DEG_SCF_TRCP1_1	310:315	Mutation rewiring degron network	0.2778
p.S318C	DO50828	LICA	ICGC	DSGFNS	DEG_SCF_TRCP1_1	310:315	Mutation blocking phosphorylation signal	0.6944
p.R325I	DO36556	READ	ICGC	DSGFNS	DEG_SCF_TRCP1_1	310:315	Mutation rewiring degron network	0.0556
p.S318N	SIDM00585	Hepatocellular Carcinoma	GDSC	DSGFNS	DEG_SCF_TRCP1_1	310:315	Mutation blocking phosphorylation signal	0.6944
p.S318N	ACH-000480	Liver Cancer	CCLE	DSGFNS	DEG_SCF_TRCP1_1	310:315	Mutation blocking phosphorylation signal	0.6944
p.S318N	ACH-000985	Colon/Colorectal Cancer	CCLE	DSGFNS	DEG_SCF_TRCP1_1	310:315	Mutation blocking phosphorylation signal	0.6944
p.S318N	HuH-7	liver	COSMIC	DSGFNS	DEG_SCF_TRCP1_1	310:315	Mutation blocking phosphorylation signal	0.6944
p.S303R	SIDM00410	Other Blood Cancers	GDSC	DSGFNS	DEG_SCF_TRCP1_1	310:315	Mutation rewiring degron network	0.1389
p.S303R	ACH-002317	Leukemia	CCLE	DSGFNS	DEG_SCF_TRCP1_1	310:315	Mutation rewiring degron network	0.1389
p.S303R	YT	haematopoietic and lymphoid tissue	COSMIC	DSGFNS	DEG_SCF_TRCP1_1	310:315	Mutation rewiring degron network	0.1389
p.R324H	no-11	central nervous system	COSMIC	DSGFNS	DEG_SCF_TRCP1_1	310:315	Mutation blocking phosphorylation signal	0.5278
p.R318M	OC-314	ovary	COSMIC	DSGFNS	DEG_SCF_TRCP1_1	310:315	Mutation blocking phosphorylation signal	0.6944

Kaplan plot for LRCH3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRCH3

UniProt ID: Q96II8

Entrez ID: 84859

Protein name: DISP complex protein LRCH3 (Leucine-rich repeat and calponin homology domain-containing protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRCH3 in