DegronMD

Uniprot ID: Q96II8

Source protein: DISP complex protein LRCH3

Source gene: LRCH3

Class: DEG_SCF_TRCP1_1

Location: 310:315

E3 ligase: BTRC

DEGRON score: 0.9881

ASA_SCORE: 52.45

COIL: 0.624

CONS_SCORE: 0.4024

DSS_SCORE: 0.4363

HELIX: 0.2787

FCONS_SCORE: 1.0652

RIG_SCORE: 0.6642

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R322I	TCGA-A5-A1OF	UCEC	TCGA	DSGFNS	DEG_SCF_TRCP1_1	0.1389
p.R322I	DO42568	UCEC	ICGC	DSGFNS	DEG_SCF_TRCP1_1	0.1389
p.N314S	TCGA-CW-5580	KIRC	TCGA	DSGFNS	DEG_SCF_TRCP1_1	0.5958
p.N314S	DO19208	KIRC	ICGC	DSGFNS	DEG_SCF_TRCP1_1	0.5958
p.L309V	DO52605	BOCA	ICGC	DSGFNS	DEG_SCF_TRCP1_1	0.3056
p.N319K	DO51634	CESC	ICGC	DSGFNS	DEG_SCF_TRCP1_1	0.2222
p.F320V	DO6308	CESC	ICGC	DSGFNS	DEG_SCF_TRCP1_1	0.1944
p.A308S	DO229028	LICA	ICGC	DSGFNS	DEG_SCF_TRCP1_1	0.2778
p.S318C	DO50828	LICA	ICGC	DSGFNS	DEG_SCF_TRCP1_1	0.6944
p.R325I	DO36556	READ	ICGC	DSGFNS	DEG_SCF_TRCP1_1	0.0556
p.S318N	SIDM00585	Hepatocellular Carcinoma	GDSC	DSGFNS	DEG_SCF_TRCP1_1	0.6944
p.S318N	ACH-000480	Liver Cancer	CCLE	DSGFNS	DEG_SCF_TRCP1_1	0.6944
p.S318N	ACH-000985	Colon/Colorectal Cancer	CCLE	DSGFNS	DEG_SCF_TRCP1_1	0.6944
p.S318N	HuH-7	liver	COSMIC	DSGFNS	DEG_SCF_TRCP1_1	0.6944
p.S303R	SIDM00410	Other Blood Cancers	GDSC	DSGFNS	DEG_SCF_TRCP1_1	0.1389
p.S303R	ACH-002317	Leukemia	CCLE	DSGFNS	DEG_SCF_TRCP1_1	0.1389
p.S303R	YT	haematopoietic_and_lymphoid_tissue	COSMIC	DSGFNS	DEG_SCF_TRCP1_1	0.1389
p.R324H	no-11	central_nervous_system	COSMIC	DSGFNS	DEG_SCF_TRCP1_1	0.5278
p.R318M	OC-314	ovary	COSMIC	DSGFNS	DEG_SCF_TRCP1_1	0.6944

DegronMD: protein-targeted degradation, mutation and drug response to degrons