DegronMD - Q9P2F5(STOX2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D848N	TCGA-63-A5MM	LUSC	TCGA	DSGFNS	DEG_SCF_TRCP1_1	855:860	Mutation rewiring degron network	0.1389
p.D848N	DO219153	LUSC	ICGC	DSGFNS	DEG_SCF_TRCP1_1	855:860	Mutation rewiring degron network	0.1389
p.F858L	TCGA-85-6561	LUSC	TCGA	DSGFNS	DEG_SCF_TRCP1_1	855:860	Mutation altering degron motif	0.587
p.F858L	DO26518	LUSC	ICGC	DSGFNS	DEG_SCF_TRCP1_1	855:860	Mutation altering degron motif	0.587
p.G857R	TCGA-AA-3967	COAD	TCGA	DSGFNS	DEG_SCF_TRCP1_1	855:860	Mutation altering degron motif	0.7568
p.G857R	DO10124	COAD	ICGC	DSGFNS	DEG_SCF_TRCP1_1	855:860	Mutation altering degron motif	0.7568
p.P861Q	TCGA-D3-A1QA	SKCM	TCGA	DSGFNS	DEG_SCF_TRCP1_1	855:860	Mutation rewiring degron network	0.3056
p.P861Q	DO47469	SKCM	ICGC	DSGFNS	DEG_SCF_TRCP1_1	855:860	Mutation rewiring degron network	0.3056
p.R864L	TCGA-ER-A19P	SKCM	TCGA	DSGFNS	DEG_SCF_TRCP1_1	855:860	Mutation rewiring degron network	0.2222
p.R864L	DO47623	SKCM	ICGC	DSGFNS	DEG_SCF_TRCP1_1	855:860	Mutation rewiring degron network	0.2222
p.R862C	TCGA-L5-A4OX	ESCA	TCGA	DSGFNS	DEG_SCF_TRCP1_1	855:860	Mutation rewiring degron network	0.2778
p.R862C	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	DSGFNS	DEG_SCF_TRCP1_1	855:860	Mutation rewiring degron network	0.2778
p.R862C	SIDM00426	Rhabdomyosarcoma	GDSC	DSGFNS	DEG_SCF_TRCP1_1	855:860	Mutation rewiring degron network	0.2778
p.S846I	DO233266	GACA	ICGC	DSGFNS	DEG_SCF_TRCP1_1	855:860	Mutation rewiring degron network	0.0833
p.R864Q	SIDM02035	Colorectal Carcinoma	GDSC	DSGFNS	DEG_SCF_TRCP1_1	855:860	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons