DegronMD

Uniprot ID: Q9P2F5

Source protein: Storkhead-box protein 2

Source gene: STOX2

Class: DEG_SCF_TRCP1_1

Location: 855:860

E3 ligase: BTRC

DEGRON score: 0.992

ASA_SCORE: 82.1833

COIL: 0.9387

CONS_SCORE: 0.5328

DSS_SCORE: 0.5836

HELIX: 0.0368

FCONS_SCORE: 0.9166

RIG_SCORE: 0.6292

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D848N	TCGA-63-A5MM	LUSC	TCGA	DSGFNS	DEG_SCF_TRCP1_1	0.1389
p.D848N	DO219153	LUSC	ICGC	DSGFNS	DEG_SCF_TRCP1_1	0.1389
p.F858L	TCGA-85-6561	LUSC	TCGA	DSGFNS	DEG_SCF_TRCP1_1	0.587
p.F858L	DO26518	LUSC	ICGC	DSGFNS	DEG_SCF_TRCP1_1	0.587
p.G857R	TCGA-AA-3967	COAD	TCGA	DSGFNS	DEG_SCF_TRCP1_1	0.7568
p.G857R	DO10124	COAD	ICGC	DSGFNS	DEG_SCF_TRCP1_1	0.7568
p.P861Q	TCGA-D3-A1QA	SKCM	TCGA	DSGFNS	DEG_SCF_TRCP1_1	0.3056
p.P861Q	DO47469	SKCM	ICGC	DSGFNS	DEG_SCF_TRCP1_1	0.3056
p.R864L	TCGA-ER-A19P	SKCM	TCGA	DSGFNS	DEG_SCF_TRCP1_1	0.2222
p.R864L	DO47623	SKCM	ICGC	DSGFNS	DEG_SCF_TRCP1_1	0.2222
p.R862C	TCGA-L5-A4OX	ESCA	TCGA	DSGFNS	DEG_SCF_TRCP1_1	0.2778
p.R862C	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	DSGFNS	DEG_SCF_TRCP1_1	0.2778
p.R862C	SIDM00426	Rhabdomyosarcoma	GDSC	DSGFNS	DEG_SCF_TRCP1_1	0.2778
p.S846I	DO233266	GACA	ICGC	DSGFNS	DEG_SCF_TRCP1_1	0.0833
p.R864Q	SIDM02035	Colorectal Carcinoma	GDSC	DSGFNS	DEG_SCF_TRCP1_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons