DegronMD - Q4G163(FBXO43)

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G603V	TCGA-18-5595	LUSC	TCGA	VLTPLAS	DEG_SCF_FBW7_1	605:611	Mutation rewiring degron network	0.2778
p.G603V	DO27373	LUSC	ICGC	VLTPLAS	DEG_SCF_FBW7_1	605:611	Mutation rewiring degron network	0.2778
p.V324A	TCGA-A6-6653	COAD	TCGA	ISTPEDS	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.2222
p.V324A	TCGA-A6-6653	COAD	TCGA	DSGFNS	DEG_SCF_TRCP1_1	333:338	Mutation rewiring degron network	0.0833
p.V324A	DO10373	COAD	ICGC	ISTPEDS	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.2222
p.V324A	DO10373	COAD	ICGC	DSGFNS	DEG_SCF_TRCP1_1	333:338	Mutation rewiring degron network	0.0833
p.E332K	TCGA-A8-A0A7	BRCA	TCGA	ISTPEDS	DEG_SCF_FBW7_1	328:334	Mutation altering degron motif	0.591
p.E332K	DO5936	BRCA	ICGC	ISTPEDS	DEG_SCF_FBW7_1	328:334	Mutation altering degron motif	0.591
p.L348P	TCGA-AG-3584	READ	TCGA	DSGFNS	DEG_SCF_TRCP1_1	333:338	Mutation rewiring degron network	0.0556
p.L348P	DO37173	READ	ICGC	DSGFNS	DEG_SCF_TRCP1_1	333:338	Mutation rewiring degron network	0.0556
p.E342D	TCGA-B5-A0JY	UCEC	TCGA	ISTPEDS	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.1111
p.E342D	TCGA-B5-A0JY	UCEC	TCGA	DSGFNS	DEG_SCF_TRCP1_1	333:338	Mutation rewiring degron network	0.2222
p.E342D	TCGA-D1-A103	UCEC	TCGA	ISTPEDS	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.1111
p.E342D	TCGA-D1-A103	UCEC	TCGA	DSGFNS	DEG_SCF_TRCP1_1	333:338	Mutation rewiring degron network	0.2222
p.E342D	DO8898	COAD	ICGC	ISTPEDS	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.1111
p.E342D	DO8898	COAD	ICGC	DSGFNS	DEG_SCF_TRCP1_1	333:338	Mutation rewiring degron network	0.2222
p.E342D	DO42312	UCEC	ICGC	ISTPEDS	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.1111
p.E342D	DO42312	UCEC	ICGC	DSGFNS	DEG_SCF_TRCP1_1	333:338	Mutation rewiring degron network	0.2222
p.E342D	DO43041	UCEC	ICGC	ISTPEDS	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.1111
p.E342D	DO43041	UCEC	ICGC	DSGFNS	DEG_SCF_TRCP1_1	333:338	Mutation rewiring degron network	0.2222
p.S327R	TCGA-B5-A3FC	UCEC	TCGA	ISTPEDS	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.3056
p.S327R	TCGA-B5-A3FC	UCEC	TCGA	DSGFNS	DEG_SCF_TRCP1_1	333:338	Mutation rewiring degron network	0.1667
p.S327R	DO41871	UCEC	ICGC	ISTPEDS	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.3056
p.S327R	DO41871	UCEC	ICGC	DSGFNS	DEG_SCF_TRCP1_1	333:338	Mutation rewiring degron network	0.1667
p.S344L	TCGA-EB-A3XD	SKCM	TCGA	ISTPEDS	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.0556
p.S344L	TCGA-EB-A3XD	SKCM	TCGA	DSGFNS	DEG_SCF_TRCP1_1	333:338	Mutation rewiring degron network	0.1667
p.S344L	DO37871	SKCM	ICGC	ISTPEDS	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.0556
p.S344L	DO37871	SKCM	ICGC	DSGFNS	DEG_SCF_TRCP1_1	333:338	Mutation rewiring degron network	0.1667
p.D346Y	TCGA-EO-A3B0	UCEC	TCGA	DSGFNS	DEG_SCF_TRCP1_1	333:338	Mutation rewiring degron network	0.1111
p.D346Y	DO219773	UCEC	ICGC	DSGFNS	DEG_SCF_TRCP1_1	333:338	Mutation rewiring degron network	0.1111
p.D346Y	SIDM01588	Endometrial Carcinoma	GDSC	DSGFNS	DEG_SCF_TRCP1_1	333:338	Mutation rewiring degron network	0.1111
p.D346Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSGFNS	DEG_SCF_TRCP1_1	333:338	Mutation rewiring degron network	0.1111
p.S612C	TCGA-FD-A62P	BLCA	TCGA	VLTPLAS	DEG_SCF_FBW7_1	605:611	Mutation rewiring degron network	0.3056
p.S612C	DO44054	BLCA	ICGC	VLTPLAS	DEG_SCF_FBW7_1	605:611	Mutation rewiring degron network	0.3056
p.S347F	TCGA-FW-A3R5	SKCM	TCGA	DSGFNS	DEG_SCF_TRCP1_1	333:338	Mutation rewiring degron network	0.0833
p.S347F	DO37406	SKCM	ICGC	DSGFNS	DEG_SCF_TRCP1_1	333:338	Mutation rewiring degron network	0.0833
p.L609P	TCGA-G4-6586	COAD	TCGA	VLTPLAS	DEG_SCF_FBW7_1	605:611	Mutation altering degron motif	0.6471
p.L609P	TCGA-XF-A9T0	BLCA	TCGA	VLTPLAS	DEG_SCF_FBW7_1	605:611	Mutation altering degron motif	0.6471
p.L609P	DO51920	BLCA	ICGC	VLTPLAS	DEG_SCF_FBW7_1	605:611	Mutation altering degron motif	0.6471
p.L609P	DO9698	COAD	ICGC	VLTPLAS	DEG_SCF_FBW7_1	605:611	Mutation altering degron motif	0.6471
p.P320H	TCGA-WE-A8K4	SKCM	TCGA	ISTPEDS	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.1111
p.P320H	DO51281	SKCM	ICGC	ISTPEDS	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.1111
p.P601S	TCGA-WE-A8ZT	SKCM	TCGA	VLTPLAS	DEG_SCF_FBW7_1	605:611	Mutation rewiring degron network	0.2222
p.P601S	DO51290	SKCM	ICGC	VLTPLAS	DEG_SCF_FBW7_1	605:611	Mutation rewiring degron network	0.2222
p.S612F	DO233779	GACA	ICGC	VLTPLAS	DEG_SCF_FBW7_1	605:611	Mutation rewiring degron network	0.3056
p.T330K	DO229018	LICA	ICGC	ISTPEDS	DEG_SCF_FBW7_1	328:334	Mutation altering degron motif	0.7306
p.T330M	DO50734	ORCA	ICGC	ISTPEDS	DEG_SCF_FBW7_1	328:334	Mutation altering degron motif	0.7423
p.T330M	ACH-001651	Endometrial/Uterine Cancer	CCLE	ISTPEDS	DEG_SCF_FBW7_1	328:334	Mutation altering degron motif	0.7423
p.F336S	SIDM00216	Colorectal Carcinoma	GDSC	DSGFNS	DEG_SCF_TRCP1_1	333:338	Mutation altering degron motif	0.6871
p.F336S	ACH-000989	Colon/Colorectal Cancer	CCLE	DSGFNS	DEG_SCF_TRCP1_1	333:338	Mutation altering degron motif	0.6871
p.F336S	SNU-175	large intestine	COSMIC	DSGFNS	DEG_SCF_TRCP1_1	333:338	Mutation altering degron motif	0.6871
p.L609V	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	VLTPLAS	DEG_SCF_FBW7_1	605:611	Mutation altering degron motif	0.5654
p.L609V	ACH-002215	Lymphoma	CCLE	VLTPLAS	DEG_SCF_FBW7_1	605:611	Mutation altering degron motif	0.5654
p.L609V	BC-3	haematopoietic and lymphoid tissue	COSMIC	VLTPLAS	DEG_SCF_FBW7_1	605:611	Mutation altering degron motif	0.5654
p.D346G	SIDM00518	Mesothelioma	GDSC	DSGFNS	DEG_SCF_TRCP1_1	333:338	Mutation rewiring degron network	0.1111
p.D346G	ACH-002136	Lung Cancer	CCLE	DSGFNS	DEG_SCF_TRCP1_1	333:338	Mutation rewiring degron network	0.1111
p.D346G	H290	pleura	COSMIC	DSGFNS	DEG_SCF_TRCP1_1	333:338	Mutation rewiring degron network	0.1111
p.L341M	ACH-000057	Myeloma	CCLE	ISTPEDS	DEG_SCF_FBW7_1	328:334	Mutation rewiring degron network	0.1389
p.L341M	ACH-000057	Myeloma	CCLE	DSGFNS	DEG_SCF_TRCP1_1	333:338	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FBXO43

UniProt ID: Q4G163

Entrez ID: 286151

Protein name: F-box only protein 43 (Endogenous meiotic inhibitor 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FBXO43 in