DegronMD

Uniprot ID: Q4G163

Source protein: F-box only protein 43

Source gene: FBXO43

Class: DEG_SCF_FBW7_1

Location: 328:334

E3 ligase: FBXW7

DEGRON score: 0.9986

ASA_SCORE: 72.8143

COIL: 0.8709

CONS_SCORE: 0.5332

DSS_SCORE: 0.5655

HELIX: 0.0801

FCONS_SCORE: 1.1847

RIG_SCORE: 0.6291

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V324A	TCGA-A6-6653	COAD	TCGA	ISTPEDS	DEG_SCF_FBW7_1	0.2222
p.V324A	DO10373	COAD	ICGC	ISTPEDS	DEG_SCF_FBW7_1	0.2222
p.E332K	TCGA-A8-A0A7	BRCA	TCGA	ISTPEDS	DEG_SCF_FBW7_1	0.591
p.E332K	DO5936	BRCA	ICGC	ISTPEDS	DEG_SCF_FBW7_1	0.591
p.E342D	TCGA-B5-A0JY	UCEC	TCGA	ISTPEDS	DEG_SCF_FBW7_1	0.1111
p.E342D	TCGA-D1-A103	UCEC	TCGA	ISTPEDS	DEG_SCF_FBW7_1	0.1111
p.E342D	DO8898	COAD	ICGC	ISTPEDS	DEG_SCF_FBW7_1	0.1111
p.E342D	DO42312	UCEC	ICGC	ISTPEDS	DEG_SCF_FBW7_1	0.1111
p.E342D	DO43041	UCEC	ICGC	ISTPEDS	DEG_SCF_FBW7_1	0.1111
p.S327R	TCGA-B5-A3FC	UCEC	TCGA	ISTPEDS	DEG_SCF_FBW7_1	0.3056
p.S327R	DO41871	UCEC	ICGC	ISTPEDS	DEG_SCF_FBW7_1	0.3056
p.S344L	TCGA-EB-A3XD	SKCM	TCGA	ISTPEDS	DEG_SCF_FBW7_1	0.0556
p.S344L	DO37871	SKCM	ICGC	ISTPEDS	DEG_SCF_FBW7_1	0.0556
p.P320H	TCGA-WE-A8K4	SKCM	TCGA	ISTPEDS	DEG_SCF_FBW7_1	0.1111
p.P320H	DO51281	SKCM	ICGC	ISTPEDS	DEG_SCF_FBW7_1	0.1111
p.T330K	DO229018	LICA	ICGC	ISTPEDS	DEG_SCF_FBW7_1	0.7306
p.T330M	DO50734	ORCA	ICGC	ISTPEDS	DEG_SCF_FBW7_1	0.7423
p.T330M	ACH-001651	Endometrial/Uterine Cancer	CCLE	ISTPEDS	DEG_SCF_FBW7_1	0.7423
p.L341M	ACH-000057	Myeloma	CCLE	ISTPEDS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4G163	F-box only protein 43	DEG_SCF_FBW7_1	328:334	ISTPEDS	FBXW7	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons