DegronMD

Uniprot ID: Q4G163

Source protein: F-box only protein 43

Source gene: FBXO43

Class: DEG_SCF_FBW7_1

Location: 605:611

E3 ligase: FBXW7

DEGRON score: 0.9988

ASA_SCORE: 77.2286

COIL: 0.7603

CONS_SCORE: 0.4371

DSS_SCORE: 0.3742

HELIX: 0.041

FCONS_SCORE: 0.9703

RIG_SCORE: 0.7344

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G603V	TCGA-18-5595	LUSC	TCGA	VLTPLAS	DEG_SCF_FBW7_1	0.2778
p.G603V	DO27373	LUSC	ICGC	VLTPLAS	DEG_SCF_FBW7_1	0.2778
p.S612C	TCGA-FD-A62P	BLCA	TCGA	VLTPLAS	DEG_SCF_FBW7_1	0.3056
p.S612C	DO44054	BLCA	ICGC	VLTPLAS	DEG_SCF_FBW7_1	0.3056
p.L609P	TCGA-G4-6586	COAD	TCGA	VLTPLAS	DEG_SCF_FBW7_1	0.6471
p.L609P	TCGA-XF-A9T0	BLCA	TCGA	VLTPLAS	DEG_SCF_FBW7_1	0.6471
p.L609P	DO51920	BLCA	ICGC	VLTPLAS	DEG_SCF_FBW7_1	0.6471
p.L609P	DO9698	COAD	ICGC	VLTPLAS	DEG_SCF_FBW7_1	0.6471
p.P601S	TCGA-WE-A8ZT	SKCM	TCGA	VLTPLAS	DEG_SCF_FBW7_1	0.2222
p.P601S	DO51290	SKCM	ICGC	VLTPLAS	DEG_SCF_FBW7_1	0.2222
p.S612F	DO233779	GACA	ICGC	VLTPLAS	DEG_SCF_FBW7_1	0.3056
p.L609V	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	VLTPLAS	DEG_SCF_FBW7_1	0.5654
p.L609V	ACH-002215	Lymphoma	CCLE	VLTPLAS	DEG_SCF_FBW7_1	0.5654
p.L609V	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	VLTPLAS	DEG_SCF_FBW7_1	0.5654

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4G163	F-box only protein 43	DEG_SCF_FBW7_1	605:611	VLTPLAS	FBXW7	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons