DegronMD

Uniprot ID: Q4G163

Source protein: F-box only protein 43

Source gene: FBXO43

Class: DEG_SCF_TRCP1_1

Location: 333:338

E3 ligase: BTRC

DEGRON score: 0.999

ASA_SCORE: 54.8167

COIL: 0.7058

CONS_SCORE: 0.6062

DSS_SCORE: 0.5591

HELIX: 0.1942

FCONS_SCORE: 1.3964

RIG_SCORE: 0.6293

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V324A	TCGA-A6-6653	COAD	TCGA	DSGFNS	DEG_SCF_TRCP1_1	0.0833
p.V324A	DO10373	COAD	ICGC	DSGFNS	DEG_SCF_TRCP1_1	0.0833
p.L348P	TCGA-AG-3584	READ	TCGA	DSGFNS	DEG_SCF_TRCP1_1	0.0556
p.L348P	DO37173	READ	ICGC	DSGFNS	DEG_SCF_TRCP1_1	0.0556
p.E342D	TCGA-B5-A0JY	UCEC	TCGA	DSGFNS	DEG_SCF_TRCP1_1	0.2222
p.E342D	TCGA-D1-A103	UCEC	TCGA	DSGFNS	DEG_SCF_TRCP1_1	0.2222
p.E342D	DO8898	COAD	ICGC	DSGFNS	DEG_SCF_TRCP1_1	0.2222
p.E342D	DO42312	UCEC	ICGC	DSGFNS	DEG_SCF_TRCP1_1	0.2222
p.E342D	DO43041	UCEC	ICGC	DSGFNS	DEG_SCF_TRCP1_1	0.2222
p.S327R	TCGA-B5-A3FC	UCEC	TCGA	DSGFNS	DEG_SCF_TRCP1_1	0.1667
p.S327R	DO41871	UCEC	ICGC	DSGFNS	DEG_SCF_TRCP1_1	0.1667
p.S344L	TCGA-EB-A3XD	SKCM	TCGA	DSGFNS	DEG_SCF_TRCP1_1	0.1667
p.S344L	DO37871	SKCM	ICGC	DSGFNS	DEG_SCF_TRCP1_1	0.1667
p.D346Y	TCGA-EO-A3B0	UCEC	TCGA	DSGFNS	DEG_SCF_TRCP1_1	0.1111
p.D346Y	DO219773	UCEC	ICGC	DSGFNS	DEG_SCF_TRCP1_1	0.1111
p.D346Y	SIDM01588	Endometrial Carcinoma	GDSC	DSGFNS	DEG_SCF_TRCP1_1	0.1111
p.D346Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSGFNS	DEG_SCF_TRCP1_1	0.1111
p.S347F	TCGA-FW-A3R5	SKCM	TCGA	DSGFNS	DEG_SCF_TRCP1_1	0.0833
p.S347F	DO37406	SKCM	ICGC	DSGFNS	DEG_SCF_TRCP1_1	0.0833
p.F336S	SIDM00216	Colorectal Carcinoma	GDSC	DSGFNS	DEG_SCF_TRCP1_1	0.6871
p.F336S	ACH-000989	Colon/Colorectal Cancer	CCLE	DSGFNS	DEG_SCF_TRCP1_1	0.6871
p.F336S	SNU-175	large_intestine	COSMIC	DSGFNS	DEG_SCF_TRCP1_1	0.6871
p.D346G	SIDM00518	Mesothelioma	GDSC	DSGFNS	DEG_SCF_TRCP1_1	0.1111
p.D346G	ACH-002136	Lung Cancer	CCLE	DSGFNS	DEG_SCF_TRCP1_1	0.1111
p.D346G	H290	pleura	COSMIC	DSGFNS	DEG_SCF_TRCP1_1	0.1111
p.L341M	ACH-000057	Myeloma	CCLE	DSGFNS	DEG_SCF_TRCP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4G163	F-box only protein 43	DEG_SCF_TRCP1_1	333:338	DSGFNS	BTRC	0.999	More...
Q96II8	DISP complex protein LRCH3	DEG_SCF_TRCP1_1	310:315	DSGFNS	BTRC	0.9881	More...
Q9P2F5	Storkhead-box protein 2	DEG_SCF_TRCP1_1	855:860	DSGFNS	BTRC	0.992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGFNS

Degron related mutations and impact score

Drug responses associated with FBXO43 mutations

All proteins holding degron of DSGFNS