DegronMD - Q96IJ6(GMPPA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N304D	TCGA-AP-A0LM	UCEC	TCGA	HPTAKVAPS	DEG_SIAH_1	290:298	Mutation rewiring degron network	0.1667
p.N304D	DO43306	UCEC	ICGC	HPTAKVAPS	DEG_SIAH_1	290:298	Mutation rewiring degron network	0.1667
p.P291L	TCGA-BR-7707	STAD	TCGA	HPTAKVAPS	DEG_SIAH_1	290:298	Mutation altering degron motif	0.7582
p.P291L	DO38487	STAD	ICGC	HPTAKVAPS	DEG_SIAH_1	290:298	Mutation altering degron motif	0.7582
p.S306F	TCGA-D3-A8GK	SKCM	TCGA	HPTAKVAPS	DEG_SIAH_1	290:298	Mutation blocking phosphorylation signal	0.5556
p.S306F	DO50286	SKCM	ICGC	HPTAKVAPS	DEG_SIAH_1	290:298	Mutation blocking phosphorylation signal	0.5556
p.P303S	TCGA-GN-A26C	SKCM	TCGA	HPTAKVAPS	DEG_SIAH_1	290:298	Mutation rewiring degron network	0.1944
p.P303S	DO37782	SKCM	ICGC	HPTAKVAPS	DEG_SIAH_1	290:298	Mutation rewiring degron network	0.1944
p.A293T	TCGA-N6-A4VD	UCS	TCGA	HPTAKVAPS	DEG_SIAH_1	290:298	Mutation altering degron motif	0.7139
p.R284Q	DO689	BLCA	ICGC	HPTAKVAPS	DEG_SIAH_1	290:298	Mutation rewiring degron network	0.1667
p.S308L	DO6254	CESC	ICGC	HPTAKVAPS	DEG_SIAH_1	290:298	Mutation rewiring degron network	0.0556
p.G280C	DO229037	LICA	ICGC	HPTAKVAPS	DEG_SIAH_1	290:298	Mutation rewiring degron network	0.0556
p.V305A	DO50922	LICA	ICGC	HPTAKVAPS	DEG_SIAH_1	290:298	Mutation rewiring degron network	0.1389
p.S298L	DO230961	LUSC	ICGC	HPTAKVAPS	DEG_SIAH_1	290:298	Mutation altering degron motif	0.6556
p.S298L	DO224594	LUSC	ICGC	HPTAKVAPS	DEG_SIAH_1	290:298	Mutation altering degron motif	0.6556
p.W282L	SIDM01196	Hepatocellular Carcinoma	GDSC	HPTAKVAPS	DEG_SIAH_1	290:298	Mutation rewiring degron network	0.1111
p.W282L	SNU-475	liver	COSMIC	HPTAKVAPS	DEG_SIAH_1	290:298	Mutation rewiring degron network	0.1111

Kaplan plot for GMPPA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GMPPA

UniProt ID: Q96IJ6

Entrez ID: 29926

Protein name: Mannose-1-phosphate guanyltransferase alpha (GDP-mannose pyrophosphorylase A) (GMPP-alpha) (GTP-mannose-1-phosphate guanylyltransferase alpha)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GMPPA in