DegronMD

Uniprot ID: Q96IJ6

Source protein: Mannose-1-phosphate guanyltransferase alpha

Source gene: GMPPA

Class: DEG_SIAH_1

Location: 290:298

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.6245

ASA_SCORE: 64.5222

COIL: 0.7431

CONS_SCORE: 0.4058

DSS_SCORE: 0.2438

HELIX: 0.0042

FCONS_SCORE: 1.0194

RIG_SCORE: 0.7969

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N304D	TCGA-AP-A0LM	UCEC	TCGA	HPTAKVAPS	DEG_SIAH_1	0.1667
p.N304D	DO43306	UCEC	ICGC	HPTAKVAPS	DEG_SIAH_1	0.1667
p.P291L	TCGA-BR-7707	STAD	TCGA	HPTAKVAPS	DEG_SIAH_1	0.7582
p.P291L	DO38487	STAD	ICGC	HPTAKVAPS	DEG_SIAH_1	0.7582
p.S306F	TCGA-D3-A8GK	SKCM	TCGA	HPTAKVAPS	DEG_SIAH_1	0.5556
p.S306F	DO50286	SKCM	ICGC	HPTAKVAPS	DEG_SIAH_1	0.5556
p.P303S	TCGA-GN-A26C	SKCM	TCGA	HPTAKVAPS	DEG_SIAH_1	0.1944
p.P303S	DO37782	SKCM	ICGC	HPTAKVAPS	DEG_SIAH_1	0.1944
p.A293T	TCGA-N6-A4VD	UCS	TCGA	HPTAKVAPS	DEG_SIAH_1	0.7139
p.R284Q	DO689	BLCA	ICGC	HPTAKVAPS	DEG_SIAH_1	0.1667
p.S308L	DO6254	CESC	ICGC	HPTAKVAPS	DEG_SIAH_1	0.0556
p.G280C	DO229037	LICA	ICGC	HPTAKVAPS	DEG_SIAH_1	0.0556
p.V305A	DO50922	LICA	ICGC	HPTAKVAPS	DEG_SIAH_1	0.1389
p.S298L	DO230961	LUSC	ICGC	HPTAKVAPS	DEG_SIAH_1	0.6556
p.S298L	DO224594	LUSC	ICGC	HPTAKVAPS	DEG_SIAH_1	0.6556
p.W282L	SIDM01196	Hepatocellular Carcinoma	GDSC	HPTAKVAPS	DEG_SIAH_1	0.1111
p.W282L	SNU-475	liver	COSMIC	HPTAKVAPS	DEG_SIAH_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96IJ6	Mannose-1-phosphate guanyltransferase alpha	DEG_SIAH_1	290:298	HPTAKVAPS	SIAH1,SIAH2,SIAH3	0.6245	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons