DegronMD - Q96IY1(NSL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E233D	TCGA-AP-A1DV	UCEC	TCGA	IETTPTET	DEG_SCF_FBW7_1	239:246	Mutation rewiring degron network	0.1667
p.E233D	TCGA-EI-6917	READ	TCGA	IETTPTET	DEG_SCF_FBW7_1	239:246	Mutation rewiring degron network	0.1667
p.E233D	DO36881	READ	ICGC	IETTPTET	DEG_SCF_FBW7_1	239:246	Mutation rewiring degron network	0.1667
p.E233D	DO43186	UCEC	ICGC	IETTPTET	DEG_SCF_FBW7_1	239:246	Mutation rewiring degron network	0.1667
p.T244R	TCGA-BH-A0C0	BRCA	TCGA	IETTPTET	DEG_SCF_FBW7_1	239:246	Mutation altering degron motif	0.6765
p.T244R	DO3194	BRCA	ICGC	IETTPTET	DEG_SCF_FBW7_1	239:246	Mutation altering degron motif	0.6765
p.M254V	DO222990	BTCA	ICGC	IETTPTET	DEG_SCF_FBW7_1	239:246	Mutation rewiring degron network	0.1111
p.M254V	DO229010	COCA	ICGC	IETTPTET	DEG_SCF_FBW7_1	239:246	Mutation rewiring degron network	0.1111
p.M254V	DO229013	COCA	ICGC	IETTPTET	DEG_SCF_FBW7_1	239:246	Mutation rewiring degron network	0.1111
p.M254V	DO229003	COCA	ICGC	IETTPTET	DEG_SCF_FBW7_1	239:246	Mutation rewiring degron network	0.1111
p.M254V	DO229005	COCA	ICGC	IETTPTET	DEG_SCF_FBW7_1	239:246	Mutation rewiring degron network	0.1111
p.M254V	DO228941	LICA	ICGC	IETTPTET	DEG_SCF_FBW7_1	239:246	Mutation rewiring degron network	0.1111
p.M254V	DO228947	LICA	ICGC	IETTPTET	DEG_SCF_FBW7_1	239:246	Mutation rewiring degron network	0.1111
p.M254V	DO52365	LUSC	ICGC	IETTPTET	DEG_SCF_FBW7_1	239:246	Mutation rewiring degron network	0.1111
p.T246A	DO52655	MALY	ICGC	IETTPTET	DEG_SCF_FBW7_1	239:246	Mutation altering degron motif	0.7139
p.T244I	SIDM00928	Breast Carcinoma	GDSC	IETTPTET	DEG_SCF_FBW7_1	239:246	Mutation altering degron motif	0.5966
p.T244I	ACH-000857	Breast Cancer	CCLE	IETTPTET	DEG_SCF_FBW7_1	239:246	Mutation altering degron motif	0.5966
p.T244I	CAL-85-1	breast	COSMIC	IETTPTET	DEG_SCF_FBW7_1	239:246	Mutation altering degron motif	0.5966

Kaplan plot for NSL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NSL1

UniProt ID: Q96IY1

Entrez ID: 25936

Protein name: Kinetochore-associated protein NSL1 homolog

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NSL1 in