DegronMD

Uniprot ID: Q96IY1

Source protein: Kinetochore-associated protein NSL1 homolog

Source gene: NSL1

Class: DEG_SCF_FBW7_1

Location: 239:246

E3 ligase: FBXW7

DEGRON score: 0.9124

ASA_SCORE: 88.325

COIL: 0.8636

CONS_SCORE: 0.3847

DSS_SCORE: 0.5561

HELIX: 0.0436

FCONS_SCORE: 1.0368

RIG_SCORE: 0.7328

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E233D	TCGA-AP-A1DV	UCEC	TCGA	IETTPTET	DEG_SCF_FBW7_1	0.1667
p.E233D	TCGA-EI-6917	READ	TCGA	IETTPTET	DEG_SCF_FBW7_1	0.1667
p.E233D	DO36881	READ	ICGC	IETTPTET	DEG_SCF_FBW7_1	0.1667
p.E233D	DO43186	UCEC	ICGC	IETTPTET	DEG_SCF_FBW7_1	0.1667
p.T244R	TCGA-BH-A0C0	BRCA	TCGA	IETTPTET	DEG_SCF_FBW7_1	0.6765
p.T244R	DO3194	BRCA	ICGC	IETTPTET	DEG_SCF_FBW7_1	0.6765
p.M254V	DO222990	BTCA	ICGC	IETTPTET	DEG_SCF_FBW7_1	0.1111
p.M254V	DO229010	COCA	ICGC	IETTPTET	DEG_SCF_FBW7_1	0.1111
p.M254V	DO229013	COCA	ICGC	IETTPTET	DEG_SCF_FBW7_1	0.1111
p.M254V	DO229003	COCA	ICGC	IETTPTET	DEG_SCF_FBW7_1	0.1111
p.M254V	DO229005	COCA	ICGC	IETTPTET	DEG_SCF_FBW7_1	0.1111
p.M254V	DO228941	LICA	ICGC	IETTPTET	DEG_SCF_FBW7_1	0.1111
p.M254V	DO228947	LICA	ICGC	IETTPTET	DEG_SCF_FBW7_1	0.1111
p.M254V	DO52365	LUSC	ICGC	IETTPTET	DEG_SCF_FBW7_1	0.1111
p.T246A	DO52655	MALY	ICGC	IETTPTET	DEG_SCF_FBW7_1	0.7139
p.T244I	SIDM00928	Breast Carcinoma	GDSC	IETTPTET	DEG_SCF_FBW7_1	0.5966
p.T244I	ACH-000857	Breast Cancer	CCLE	IETTPTET	DEG_SCF_FBW7_1	0.5966
p.T244I	CAL-85-1	breast	COSMIC	IETTPTET	DEG_SCF_FBW7_1	0.5966

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96IY1	Kinetochore-associated protein NSL1 homolog	DEG_SCF_FBW7_1	239:246	IETTPTET	FBXW7	0.9124	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons