DegronMD - Q96J94(PIWIL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K101N	TCGA-A5-A0G2	UCEC	TCGA	TRQNLDHVK	DEG_APCC_DBOX_1	93:101	Mutation altering degron motif	0.5806
p.K101N	DO41235	UCEC	ICGC	TRQNLDHVK	DEG_APCC_DBOX_1	93:101	Mutation altering degron motif	0.5806
p.E102K	TCGA-AP-A0LM	UCEC	TCGA	TRQNLDHVK	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.3056
p.E102K	DO43306	UCEC	ICGC	TRQNLDHVK	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.3056
p.R83H	TCGA-D5-6930	COAD	TCGA	TRQNLDHVK	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.0556
p.R83H	DO10550	COAD	ICGC	TRQNLDHVK	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.0556
p.D85Y	TCGA-E6-A1LX	UCEC	TCGA	TRQNLDHVK	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.1111
p.D85Y	DO41020	UCEC	ICGC	TRQNLDHVK	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.1111
p.D85Y	SIDM00282	Colorectal Carcinoma	GDSC	TRQNLDHVK	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.1111
p.D85Y	ACH-000998	Colon/Colorectal Cancer	CCLE	TRQNLDHVK	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.1111
p.D85Y	CW-2	large intestine	COSMIC	TRQNLDHVK	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.1111
p.N96H	TCGA-EE-A2GC	SKCM	TCGA	TRQNLDHVK	DEG_APCC_DBOX_1	93:101	Mutation altering degron motif	0.6312
p.N96H	DO37839	SKCM	ICGC	TRQNLDHVK	DEG_APCC_DBOX_1	93:101	Mutation altering degron motif	0.6312
p.K104E	TCGA-EO-A3B0	UCEC	TCGA	TRQNLDHVK	DEG_APCC_DBOX_1	93:101	Mutation substituting flanking lysine	0.3611
p.K104E	DO219773	UCEC	ICGC	TRQNLDHVK	DEG_APCC_DBOX_1	93:101	Mutation substituting flanking lysine	0.3611
p.K101E	DO224985	BRCA	ICGC	TRQNLDHVK	DEG_APCC_DBOX_1	93:101	Mutation altering degron motif	0.591
p.R83C	DO222798	COCA	ICGC	TRQNLDHVK	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.0556
p.R83C	DO231805	LINC	ICGC	TRQNLDHVK	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.0556
p.R83C	DO220906	MELA	ICGC	TRQNLDHVK	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.0556
p.D85N	DO222749	MELA	ICGC	TRQNLDHVK	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.1111
p.H87Y	DO229502	SKCA	ICGC	TRQNLDHVK	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.1667
p.H99R	SIDM02050	Colorectal Carcinoma	GDSC	TRQNLDHVK	DEG_APCC_DBOX_1	93:101	Mutation altering degron motif	0.7133
p.S103A	SIDM02059	Colorectal Carcinoma	GDSC	TRQNLDHVK	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.2778
p.H87R	SIDM02021	Esophageal Carcinoma	GDSC	TRQNLDHVK	DEG_APCC_DBOX_1	93:101	Mutation rewiring degron network	0.1667
p.D98Y	SIDM01503	Small Cell Lung Carcinoma	GDSC	TRQNLDHVK	DEG_APCC_DBOX_1	93:101	Mutation altering degron motif	0.6214
p.D98Y	ACH-000844	Lung Cancer	CCLE	TRQNLDHVK	DEG_APCC_DBOX_1	93:101	Mutation altering degron motif	0.6214

Kaplan plot for PIWIL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PIWIL1

UniProt ID: Q96J94

Entrez ID: 9271

Protein name: Piwi-like protein 1 (EC 3.1.26.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PIWIL1 in