DegronMD

Uniprot ID: Q96J94

Source protein: Piwi-like protein 1

Source gene: PIWIL1

Class: DEG_APCC_DBOX_1

Location: 93:101

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.854

ASA_SCORE: 107.3778

COIL: 0.8829

CONS_SCORE: 0.3119

DSS_SCORE: 0.4928

HELIX: 0.0702

FCONS_SCORE: 0.9474

RIG_SCORE: 0.743

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K101N	TCGA-A5-A0G2	UCEC	TCGA	TRQNLDHVK	DEG_APCC_DBOX_1	0.5806
p.K101N	DO41235	UCEC	ICGC	TRQNLDHVK	DEG_APCC_DBOX_1	0.5806
p.E102K	TCGA-AP-A0LM	UCEC	TCGA	TRQNLDHVK	DEG_APCC_DBOX_1	0.3056
p.E102K	DO43306	UCEC	ICGC	TRQNLDHVK	DEG_APCC_DBOX_1	0.3056
p.R83H	TCGA-D5-6930	COAD	TCGA	TRQNLDHVK	DEG_APCC_DBOX_1	0.0556
p.R83H	DO10550	COAD	ICGC	TRQNLDHVK	DEG_APCC_DBOX_1	0.0556
p.D85Y	TCGA-E6-A1LX	UCEC	TCGA	TRQNLDHVK	DEG_APCC_DBOX_1	0.1111
p.D85Y	DO41020	UCEC	ICGC	TRQNLDHVK	DEG_APCC_DBOX_1	0.1111
p.D85Y	SIDM00282	Colorectal Carcinoma	GDSC	TRQNLDHVK	DEG_APCC_DBOX_1	0.1111
p.D85Y	ACH-000998	Colon/Colorectal Cancer	CCLE	TRQNLDHVK	DEG_APCC_DBOX_1	0.1111
p.D85Y	CW-2	large_intestine	COSMIC	TRQNLDHVK	DEG_APCC_DBOX_1	0.1111
p.N96H	TCGA-EE-A2GC	SKCM	TCGA	TRQNLDHVK	DEG_APCC_DBOX_1	0.6312
p.N96H	DO37839	SKCM	ICGC	TRQNLDHVK	DEG_APCC_DBOX_1	0.6312
p.K104E	TCGA-EO-A3B0	UCEC	TCGA	TRQNLDHVK	DEG_APCC_DBOX_1	0.3611
p.K104E	DO219773	UCEC	ICGC	TRQNLDHVK	DEG_APCC_DBOX_1	0.3611
p.K101E	DO224985	BRCA	ICGC	TRQNLDHVK	DEG_APCC_DBOX_1	0.591
p.R83C	DO222798	COCA	ICGC	TRQNLDHVK	DEG_APCC_DBOX_1	0.0556
p.R83C	DO231805	LINC	ICGC	TRQNLDHVK	DEG_APCC_DBOX_1	0.0556
p.R83C	DO220906	MELA	ICGC	TRQNLDHVK	DEG_APCC_DBOX_1	0.0556
p.D85N	DO222749	MELA	ICGC	TRQNLDHVK	DEG_APCC_DBOX_1	0.1111
p.H87Y	DO229502	SKCA	ICGC	TRQNLDHVK	DEG_APCC_DBOX_1	0.1667
p.H99R	SIDM02050	Colorectal Carcinoma	GDSC	TRQNLDHVK	DEG_APCC_DBOX_1	0.7133
p.S103A	SIDM02059	Colorectal Carcinoma	GDSC	TRQNLDHVK	DEG_APCC_DBOX_1	0.2778
p.H87R	SIDM02021	Esophageal Carcinoma	GDSC	TRQNLDHVK	DEG_APCC_DBOX_1	0.1667
p.D98Y	SIDM01503	Small Cell Lung Carcinoma	GDSC	TRQNLDHVK	DEG_APCC_DBOX_1	0.6214
p.D98Y	ACH-000844	Lung Cancer	CCLE	TRQNLDHVK	DEG_APCC_DBOX_1	0.6214

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96J94	Piwi-like protein 1	DEG_APCC_DBOX_1	93:101	TRQNLDHVK	APC,CDC20,FZR1	0.854	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TRQNLDHVK

Degron related mutations and impact score

Drug responses associated with PIWIL1 mutations

All proteins holding degron of TRQNLDHVK