PLEKHA8
UniProt ID: Q96JA3
Entrez ID: 84725
Protein name: Pleckstrin homology domain-containing family A member 8 (PH domain-containing family A member 8) (Phosphatidylinositol-four-phosphate adapter protein 2) (FAPP-2) (Phosphoinositol 4-phosphate adapter protein 2) (hFAPP2) (Serologically defined breast cancer antigen NY-BR-86)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma memb...
FUNCTION: Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation. {ECO:0000269|PubMed:15107860, ECO:0000269|PubMed:16103222, ECO:0000269|PubMed:17687330}.
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GO - Biological processes (BP):
ceramide transport [GO:0035627]; ER to Golgi ceramide transport [GO:0035621]; intermembrane lipid transfer [GO:0120009]; lipid transport [GO:0006869]; protein transport [GO:0015031]...
ceramide transport [GO:0035627]; ER to Golgi ceramide transport [GO:0035621]; intermembrane lipid transfer [GO:0120009]; lipid transport [GO:0006869]; protein transport [GO:0015031]
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GO - Molecular function (MF):
ceramide 1-phosphate binding [GO:1902387]; ceramide 1-phosphate transfer activity [GO:1902388]; ceramide binding [GO:0097001]; glycolipid binding [GO:0051861]; glycolipid transfer activity [GO:0017089]; phosphatidylinositol-4-phosphate binding [GO:0070273]...
ceramide 1-phosphate binding [GO:1902387]; ceramide 1-phosphate transfer activity [GO:1902388]; ceramide binding [GO:0097001]; glycolipid binding [GO:0051861]; glycolipid transfer activity [GO:0017089]; phosphatidylinositol-4-phosphate binding [GO:0070273]
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GO - Cellular component (CC):
cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; trans-Golgi network [GO:0005802]...
cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; trans-Golgi network [GO:0005802]
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PLEKHA8
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Kaplan plot for PLEKHA8 in
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*NOTE: the Kaplan plots were collected from OncoLnc