DegronMD

Uniprot ID: Q96JA3

Source protein: Pleckstrin homology domain-containing family A member 8

Source gene: PLEKHA8

Class: DEG_SCF_FBW7_1

Location: 182:189

E3 ligase: FBXW7

DEGRON score: 0.9831

ASA_SCORE: 83.7125

COIL: 0.9038

CONS_SCORE: 0.3717

DSS_SCORE: 0.3319

HELIX: 0.059

FCONS_SCORE: 1.1414

RIG_SCORE: 0.7262

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A173T	TCGA-FI-A2D0	UCEC	TCGA	LYRTPPGS	DEG_SCF_FBW7_1	0.0833
p.A173T	DO43891	UCEC	ICGC	LYRTPPGS	DEG_SCF_FBW7_1	0.0833
p.S189L	TCGA-N9-A4Q7	UCS	TCGA	LYRTPPGS	DEG_SCF_FBW7_1	0.8778
p.S197F	TCGA-WE-A8ZT	SKCM	TCGA	LYRTPPGS	DEG_SCF_FBW7_1	0.1111
p.S197F	DO51290	SKCM	ICGC	LYRTPPGS	DEG_SCF_FBW7_1	0.1111
p.M194T	DO233885	GACA	ICGC	LYRTPPGS	DEG_SCF_FBW7_1	0.1944
p.R184H	DO233882	GACA	ICGC	LYRTPPGS	DEG_SCF_FBW7_1	0.7133
p.P186S	DO232761	PBCA	ICGC	LYRTPPGS	DEG_SCF_FBW7_1	0.6752
p.M194V	SIDM00773	Non-Cancerous	GDSC	LYRTPPGS	DEG_SCF_FBW7_1	0.1944
p.M194V	SIDM01187	Breast Carcinoma	GDSC	LYRTPPGS	DEG_SCF_FBW7_1	0.1944
p.M194V	SIDM00774	Breast Carcinoma	GDSC	LYRTPPGS	DEG_SCF_FBW7_1	0.1944
p.R184S	SIDM01088	Endometrial Carcinoma	GDSC	LYRTPPGS	DEG_SCF_FBW7_1	0.6316
p.R184S	RL95-2	endometrium	COSMIC	LYRTPPGS	DEG_SCF_FBW7_1	0.6316
p.A173S	SIDM00132	Pancreatic Carcinoma	GDSC	LYRTPPGS	DEG_SCF_FBW7_1	0.0833
p.A173S	ACH-000535	Pancreatic Cancer	CCLE	LYRTPPGS	DEG_SCF_FBW7_1	0.0833
p.A173S	BxPC-3	pancreas	COSMIC	LYRTPPGS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JA3	Pleckstrin homology domain-containing family A member 8	DEG_SCF_FBW7_1	182:189	LYRTPPGS	FBXW7	0.9831	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons