DegronMD - Q96JB5(CDK5RAP3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A266E	TCGA-13-0893	OV	TCGA	ERPHLEELP	DEG_APCC_DBOX_1	251:259	Mutation rewiring degron network	0.1389
p.P253S	TCGA-C5-A7CO	CESC	TCGA	ERPHLEELP	DEG_APCC_DBOX_1	251:259	Mutation altering degron motif	0.5641
p.E256K	TCGA-N9-A4Q7	UCS	TCGA	ERPHLEELP	DEG_APCC_DBOX_1	251:259	Mutation altering degron motif	0.591
p.R267S	DO229015	LICA	ICGC	ERPHLEELP	DEG_APCC_DBOX_1	251:259	Mutation rewiring degron network	0.1111
p.V248L	DO229029	LICA	ICGC	ERPHLEELP	DEG_APCC_DBOX_1	251:259	Mutation rewiring degron network	0.25
p.M251I	DO229022	LICA	ICGC	ERPHLEELP	DEG_APCC_DBOX_1	251:259	Mutation altering degron motif	0.7618
p.P244H	DO23774	LUAD	ICGC	ERPHLEELP	DEG_APCC_DBOX_1	251:259	Mutation rewiring degron network	0.1389
p.R258W	DO41235	UCEC	ICGC	ERPHLEELP	DEG_APCC_DBOX_1	251:259	Mutation altering degron motif	0.8634
p.T262M	SIDM00773	Non-Cancerous	GDSC	ERPHLEELP	DEG_APCC_DBOX_1	251:259	Mutation rewiring degron network	0.25
p.T262M	SIDM00878	Breast Carcinoma	GDSC	ERPHLEELP	DEG_APCC_DBOX_1	251:259	Mutation rewiring degron network	0.25
p.T262M	SIDM00720	Mesothelioma	GDSC	ERPHLEELP	DEG_APCC_DBOX_1	251:259	Mutation rewiring degron network	0.25
p.T262M	SIDM01689	B-Lymphoblastic Leukemia	GDSC	ERPHLEELP	DEG_APCC_DBOX_1	251:259	Mutation rewiring degron network	0.25
p.T262A	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	ERPHLEELP	DEG_APCC_DBOX_1	251:259	Mutation rewiring degron network	0.25
p.T262A	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	ERPHLEELP	DEG_APCC_DBOX_1	251:259	Mutation rewiring degron network	0.25
p.R253W	SIDM00878	Breast Carcinoma	GDSC	ERPHLEELP	DEG_APCC_DBOX_1	251:259	Mutation altering degron motif	0.8634
p.R253W	SIDM00720	Mesothelioma	GDSC	ERPHLEELP	DEG_APCC_DBOX_1	251:259	Mutation altering degron motif	0.8634
p.R258Q	SIDM01107	Melanoma	GDSC	ERPHLEELP	DEG_APCC_DBOX_1	251:259	Mutation altering degron motif	0.7329
p.R258Q	SIDM00083	Glioblastoma	GDSC	ERPHLEELP	DEG_APCC_DBOX_1	251:259	Mutation altering degron motif	0.7329
p.R258Q	SK-MEL-1	skin	COSMIC	ERPHLEELP	DEG_APCC_DBOX_1	251:259	Mutation altering degron motif	0.7329
p.R258Q	SF539	central nervous system	COSMIC	ERPHLEELP	DEG_APCC_DBOX_1	251:259	Mutation altering degron motif	0.7329
p.E246D	ACH-000981	Leukemia	CCLE	ERPHLEELP	DEG_APCC_DBOX_1	251:259	Mutation rewiring degron network	0.1944
p.E246D	DND-41	haematopoietic and lymphoid tissue	COSMIC	ERPHLEELP	DEG_APCC_DBOX_1	251:259	Mutation rewiring degron network	0.1944

Kaplan plot for CDK5RAP3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDK5RAP3

UniProt ID: Q96JB5

Entrez ID: 80279

Protein name: CDK5 regulatory subunit-associated protein 3 (CDK5 activator-binding protein C53) (LXXLL/leucine-zipper-containing ARF-binding protein) (Protein HSF-27)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDK5RAP3 in