DegronMD

Uniprot ID: Q96JB5

Source protein: CDK5 regulatory subunit-associated protein 3

Source gene: CDK5RAP3

Class: DEG_APCC_DBOX_1

Location: 251:259

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8125

ASA_SCORE: 82.4444

COIL: 0.7122

CONS_SCORE: 0.338

DSS_SCORE: 0.5641

HELIX: 0.2379

FCONS_SCORE: 0.7553

RIG_SCORE: 0.7809

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A266E	TCGA-13-0893	OV	TCGA	ERPHLEELP	DEG_APCC_DBOX_1	0.1389
p.P253S	TCGA-C5-A7CO	CESC	TCGA	ERPHLEELP	DEG_APCC_DBOX_1	0.5641
p.E256K	TCGA-N9-A4Q7	UCS	TCGA	ERPHLEELP	DEG_APCC_DBOX_1	0.591
p.R267S	DO229015	LICA	ICGC	ERPHLEELP	DEG_APCC_DBOX_1	0.1111
p.V248L	DO229029	LICA	ICGC	ERPHLEELP	DEG_APCC_DBOX_1	0.25
p.M251I	DO229022	LICA	ICGC	ERPHLEELP	DEG_APCC_DBOX_1	0.7618
p.P244H	DO23774	LUAD	ICGC	ERPHLEELP	DEG_APCC_DBOX_1	0.1389
p.R258W	DO41235	UCEC	ICGC	ERPHLEELP	DEG_APCC_DBOX_1	0.8634
p.T262M	SIDM00773	Non-Cancerous	GDSC	ERPHLEELP	DEG_APCC_DBOX_1	0.25
p.T262M	SIDM00878	Breast Carcinoma	GDSC	ERPHLEELP	DEG_APCC_DBOX_1	0.25
p.T262M	SIDM00720	Mesothelioma	GDSC	ERPHLEELP	DEG_APCC_DBOX_1	0.25
p.T262M	SIDM01689	B-Lymphoblastic Leukemia	GDSC	ERPHLEELP	DEG_APCC_DBOX_1	0.25
p.T262A	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	ERPHLEELP	DEG_APCC_DBOX_1	0.25
p.T262A	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	ERPHLEELP	DEG_APCC_DBOX_1	0.25
p.R253W	SIDM00878	Breast Carcinoma	GDSC	ERPHLEELP	DEG_APCC_DBOX_1	0.8634
p.R253W	SIDM00720	Mesothelioma	GDSC	ERPHLEELP	DEG_APCC_DBOX_1	0.8634
p.R258Q	SIDM01107	Melanoma	GDSC	ERPHLEELP	DEG_APCC_DBOX_1	0.7329
p.R258Q	SIDM00083	Glioblastoma	GDSC	ERPHLEELP	DEG_APCC_DBOX_1	0.7329
p.R258Q	SK-MEL-1	skin	COSMIC	ERPHLEELP	DEG_APCC_DBOX_1	0.7329
p.R258Q	SF539	central_nervous_system	COSMIC	ERPHLEELP	DEG_APCC_DBOX_1	0.7329
p.E246D	ACH-000981	Leukemia	CCLE	ERPHLEELP	DEG_APCC_DBOX_1	0.1944
p.E246D	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	ERPHLEELP	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JB5	CDK5 regulatory subunit-associated protein 3	DEG_APCC_DBOX_1	251:259	ERPHLEELP	APC,CDC20,FZR1	0.8125	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons