DegronMD - Q96JC9(EAF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R80W	TCGA-AA-3864	COAD	TCGA	PGSTPPMT	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.1389
p.R80W	DO8490	COAD	ICGC	PGSTPPMT	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.1389
p.R80Q	TCGA-AX-A1CE	UCEC	TCGA	PGSTPPMT	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.1389
p.R80Q	DO42280	UCEC	ICGC	PGSTPPMT	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.1389
p.V58A	TCGA-D8-A1XK	BRCA	TCGA	PGSTPPMT	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.1111
p.V58A	DO4749	BRCA	ICGC	PGSTPPMT	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.1111
p.P67L	DO233746	GACA	ICGC	PGSTPPMT	DEG_SCF_FBW7_1	66:73	Mutation altering degron motif	0.7582
p.D81Y	DO228974	LICA	ICGC	PGSTPPMT	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.1111
p.D81Y	DO43154	UCEC	ICGC	PGSTPPMT	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.1111
p.I82S	DO31779	OV	ICGC	PGSTPPMT	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.0833
p.G77R	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	PGSTPPMT	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.2222
p.G77R	ACH-000638	Lung Cancer	CCLE	PGSTPPMT	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.2222
p.G77R	NCI-H441	lung	COSMIC	PGSTPPMT	DEG_SCF_FBW7_1	66:73	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons