DegronMD

Uniprot ID: Q96JC9

Source protein: ELL-associated factor 1

Source gene: EAF1

Class: DEG_SCF_FBW7_1

Location: 66:73

E3 ligase: FBXW7

DEGRON score: 0.9904

ASA_SCORE: 67.9125

COIL: 0.8073

CONS_SCORE: 0.5666

DSS_SCORE: 0.4669

HELIX: 0.0136

FCONS_SCORE: 0.8344

RIG_SCORE: 0.7004

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R80W	TCGA-AA-3864	COAD	TCGA	PGSTPPMT	DEG_SCF_FBW7_1	0.1389
p.R80W	DO8490	COAD	ICGC	PGSTPPMT	DEG_SCF_FBW7_1	0.1389
p.R80Q	TCGA-AX-A1CE	UCEC	TCGA	PGSTPPMT	DEG_SCF_FBW7_1	0.1389
p.R80Q	DO42280	UCEC	ICGC	PGSTPPMT	DEG_SCF_FBW7_1	0.1389
p.V58A	TCGA-D8-A1XK	BRCA	TCGA	PGSTPPMT	DEG_SCF_FBW7_1	0.1111
p.V58A	DO4749	BRCA	ICGC	PGSTPPMT	DEG_SCF_FBW7_1	0.1111
p.P67L	DO233746	GACA	ICGC	PGSTPPMT	DEG_SCF_FBW7_1	0.7582
p.D81Y	DO228974	LICA	ICGC	PGSTPPMT	DEG_SCF_FBW7_1	0.1111
p.D81Y	DO43154	UCEC	ICGC	PGSTPPMT	DEG_SCF_FBW7_1	0.1111
p.I82S	DO31779	OV	ICGC	PGSTPPMT	DEG_SCF_FBW7_1	0.0833
p.G77R	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	PGSTPPMT	DEG_SCF_FBW7_1	0.2222
p.G77R	ACH-000638	Lung Cancer	CCLE	PGSTPPMT	DEG_SCF_FBW7_1	0.2222
p.G77R	NCI-H441	lung	COSMIC	PGSTPPMT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JC9	ELL-associated factor 1	DEG_SCF_FBW7_1	66:73	PGSTPPMT	FBXW7	0.9904	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons