DegronMD - Q96JK2(DCAF5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A717V	TCGA-06-5416	GBM	TCGA	APSSS	DEG_SPOP_SBC_1	703:707	Mutation rewiring degron network	0.0556
p.K708N	TCGA-14-1794	GBM	TCGA	APSSS	DEG_SPOP_SBC_1	703:707	Mutation blocking ubiquitination signal	0.75
p.R509L	TCGA-60-2725	LUSC	TCGA	PPTPTCE	DEG_SCF_FBW7_2	498:504	Mutation rewiring degron network	0.1944
p.A717T	TCGA-AA-3833	COAD	TCGA	APSSS	DEG_SPOP_SBC_1	703:707	Mutation rewiring degron network	0.0556
p.A710V	TCGA-AX-A2HD	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	703:707	Mutation rewiring degron network	0.25
p.A703S	TCGA-FI-A2D5	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	703:707	Mutation altering degron motif	0.7588
p.T696A	TCGA-MH-A562	KIRP	TCGA	APSSS	DEG_SPOP_SBC_1	703:707	Mutation rewiring degron network	0.1389
p.L703P	DO8192	COAD	ICGC	APSSS	DEG_SPOP_SBC_1	703:707	Mutation altering degron motif	0.7582
p.A702T	DO227709	COCA	ICGC	APSSS	DEG_SPOP_SBC_1	703:707	Mutation rewiring degron network	0.3056
p.R495H	DO44451	HNSC	ICGC	PPTPTCE	DEG_SCF_FBW7_2	498:504	Mutation rewiring degron network	0.25
p.P713S	DO229177	LMS	ICGC	APSSS	DEG_SPOP_SBC_1	703:707	Mutation rewiring degron network	0.1667
p.P713S	Mewo	skin	COSMIC	APSSS	DEG_SPOP_SBC_1	703:707	Mutation rewiring degron network	0.1667
p.K696N	DO48884	LUAD	ICGC	APSSS	DEG_SPOP_SBC_1	703:707	Mutation rewiring degron network	0.1389
p.R507C	DO38328	STAD	ICGC	PPTPTCE	DEG_SCF_FBW7_2	498:504	Mutation rewiring degron network	0.25
p.R512H	SIDM00499	Prostate Carcinoma	GDSC	PPTPTCE	DEG_SCF_FBW7_2	498:504	Mutation rewiring degron network	0.1111
p.R512H	ACH-000956	Prostate Cancer	CCLE	PPTPTCE	DEG_SCF_FBW7_2	498:504	Mutation rewiring degron network	0.1111
p.R512H	22RV1	prostate	COSMIC	PPTPTCE	DEG_SCF_FBW7_2	498:504	Mutation rewiring degron network	0.1111
p.A703T	SIDM00845	Burkitt's Lymphoma	GDSC	APSSS	DEG_SPOP_SBC_1	703:707	Mutation altering degron motif	0.7139
p.A703T	SIDM00461	Acute Myeloid Leukemia	GDSC	APSSS	DEG_SPOP_SBC_1	703:707	Mutation altering degron motif	0.7139
p.C711F	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	703:707	Mutation rewiring degron network	0.2222
p.C711F	ACH-000438	Lung Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	703:707	Mutation rewiring degron network	0.2222
p.C711F	LU-65	lung	COSMIC	APSSS	DEG_SPOP_SBC_1	703:707	Mutation rewiring degron network	0.2222
p.R509H	ACH-001199	Colon/Colorectal Cancer	CCLE	PPTPTCE	DEG_SCF_FBW7_2	498:504	Mutation rewiring degron network	0.1944
p.E709G	PF-382	haematopoietic and lymphoid tissue	COSMIC	APSSS	DEG_SPOP_SBC_1	703:707	Mutation rewiring degron network	0.2778
p.F693S	LNZTA3WT4	central nervous system	COSMIC	APSSS	DEG_SPOP_SBC_1	703:707	Mutation rewiring degron network	0.0556
p.C710F	LU-65	lung	COSMIC	APSSS	DEG_SPOP_SBC_1	703:707	Mutation rewiring degron network	0.25
p.R511H	22RV1	prostate	COSMIC	PPTPTCE	DEG_SCF_FBW7_2	498:504	Mutation rewiring degron network	0.1389

Kaplan plot for DCAF5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DCAF5

UniProt ID: Q96JK2

Entrez ID: 8816

Protein name: DDB1- and CUL4-associated factor 5 (Breakpoint cluster region protein 2) (BCRP2) (WD repeat-containing protein 22)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DCAF5 in