DegronMD

Uniprot ID: Q96JK2

Source protein: DDB1- and CUL4-associated factor 5

Source gene: DCAF5

Class: DEG_SCF_FBW7_2

Location: 498:504

E3 ligase: FBXW7

DEGRON score: 0.9895

ASA_SCORE: 80.8857

COIL: 0.7851

CONS_SCORE: 0.4285

DSS_SCORE: 0.6435

HELIX: 0.1001

FCONS_SCORE: 0.8738

RIG_SCORE: 0.7101

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R509L	TCGA-60-2725	LUSC	TCGA	PPTPTCE	DEG_SCF_FBW7_2	0.1944
p.R495H	DO44451	HNSC	ICGC	PPTPTCE	DEG_SCF_FBW7_2	0.25
p.R507C	DO38328	STAD	ICGC	PPTPTCE	DEG_SCF_FBW7_2	0.25
p.R512H	SIDM00499	Prostate Carcinoma	GDSC	PPTPTCE	DEG_SCF_FBW7_2	0.1111
p.R512H	ACH-000956	Prostate Cancer	CCLE	PPTPTCE	DEG_SCF_FBW7_2	0.1111
p.R512H	22RV1	prostate	COSMIC	PPTPTCE	DEG_SCF_FBW7_2	0.1111
p.R509H	ACH-001199	Colon/Colorectal Cancer	CCLE	PPTPTCE	DEG_SCF_FBW7_2	0.1944
p.R511H	22RV1	prostate	COSMIC	PPTPTCE	DEG_SCF_FBW7_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JK2	DDB1- and CUL4-associated factor 5	DEG_SCF_FBW7_2	498:504	PPTPTCE	FBXW7	0.9895	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons