DegronMD - Q96JS3(PGBD1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E291Q	TCGA-12-1598	GBM	TCGA	PCSTPIAT	DEG_SCF_FBW7_1	297:304	Mutation rewiring degron network	0.1667
p.E291Q	DO10871	GBM	ICGC	PCSTPIAT	DEG_SCF_FBW7_1	297:304	Mutation rewiring degron network	0.1667
p.A293S	TCGA-66-2788	LUSC	TCGA	PCSTPIAT	DEG_SCF_FBW7_1	297:304	Mutation rewiring degron network	0.2222
p.A293S	DO26749	LUSC	ICGC	PCSTPIAT	DEG_SCF_FBW7_1	297:304	Mutation rewiring degron network	0.2222
p.P288H	TCGA-A6-2686	COAD	TCGA	PCSTPIAT	DEG_SCF_FBW7_1	297:304	Mutation rewiring degron network	0.0833
p.P288H	DO7828	COAD	ICGC	PCSTPIAT	DEG_SCF_FBW7_1	297:304	Mutation rewiring degron network	0.0833
p.P297L	DO222532	MELA	ICGC	PCSTPIAT	DEG_SCF_FBW7_1	297:304	Mutation altering degron motif	0.6471
p.P301H	SIDM00282	Colorectal Carcinoma	GDSC	PCSTPIAT	DEG_SCF_FBW7_1	297:304	Mutation altering degron motif	0.7694
p.P301H	ACH-000998	Colon/Colorectal Cancer	CCLE	PCSTPIAT	DEG_SCF_FBW7_1	297:304	Mutation altering degron motif	0.7694

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons