DegronMD

Uniprot ID: Q96JS3

Source protein: PiggyBac transposable element-derived protein 1

Source gene: PGBD1

Class: DEG_SCF_FBW7_1

Location: 297:304

E3 ligase: FBXW7

DEGRON score: 0.9978

ASA_SCORE: 73.2

COIL: 0.8974

CONS_SCORE: 0.3563

DSS_SCORE: 0.4966

HELIX: 0.0578

FCONS_SCORE: 0.874

RIG_SCORE: 0.7226

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E291Q	TCGA-12-1598	GBM	TCGA	PCSTPIAT	DEG_SCF_FBW7_1	0.1667
p.E291Q	DO10871	GBM	ICGC	PCSTPIAT	DEG_SCF_FBW7_1	0.1667
p.A293S	TCGA-66-2788	LUSC	TCGA	PCSTPIAT	DEG_SCF_FBW7_1	0.2222
p.A293S	DO26749	LUSC	ICGC	PCSTPIAT	DEG_SCF_FBW7_1	0.2222
p.P288H	TCGA-A6-2686	COAD	TCGA	PCSTPIAT	DEG_SCF_FBW7_1	0.0833
p.P288H	DO7828	COAD	ICGC	PCSTPIAT	DEG_SCF_FBW7_1	0.0833
p.P297L	DO222532	MELA	ICGC	PCSTPIAT	DEG_SCF_FBW7_1	0.6471
p.P301H	SIDM00282	Colorectal Carcinoma	GDSC	PCSTPIAT	DEG_SCF_FBW7_1	0.7694
p.P301H	ACH-000998	Colon/Colorectal Cancer	CCLE	PCSTPIAT	DEG_SCF_FBW7_1	0.7694

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96JS3	PiggyBac transposable element-derived protein 1	DEG_SCF_FBW7_1	297:304	PCSTPIAT	FBXW7	0.9978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons