DegronMD - Q96K37(SLC35E1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R360H	TCGA-A5-A0VP	UCEC	TCGA	ARKHLLPVT	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.0833
p.R360H	TCGA-AA-3695	COAD	TCGA	ARKHLLPVT	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.0833
p.R360H	DO7166	CLLE	ICGC	ARKHLLPVT	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.0833
p.R360H	DO10694	COAD	ICGC	ARKHLLPVT	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.0833
p.R360H	DO42600	UCEC	ICGC	ARKHLLPVT	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.0833
p.A339T	TCGA-AX-A06F	UCEC	TCGA	ARKHLLPVT	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.2222
p.A339T	DO41752	UCEC	ICGC	ARKHLLPVT	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.2222
p.V350I	TCGA-EO-A3KX	UCEC	TCGA	ARKHLLPVT	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.5965
p.V350I	DO219774	UCEC	ICGC	ARKHLLPVT	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.5965
p.Q341K	DO228952	LICA	ICGC	ARKHLLPVT	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.2778
p.H346N	DO229009	LICA	ICGC	ARKHLLPVT	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.6312
p.R360C	SIDM00789	Colorectal Carcinoma	GDSC	ARKHLLPVT	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.0833
p.R360C	SIDM00145	T-Lymphoblastic Leukemia	GDSC	ARKHLLPVT	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.0833
p.R360C	ACH-000997	Colon/Colorectal Cancer	CCLE	ARKHLLPVT	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.0833
p.R360C	ACH-001127	Leukemia	CCLE	ARKHLLPVT	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.0833
p.R360C	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	ARKHLLPVT	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.0833
p.R360C	HCT-15	large intestine	COSMIC	ARKHLLPVT	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.0833
p.V350F	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	ARKHLLPVT	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.7068
p.V350F	ACH-000860	Lung Cancer	CCLE	ARKHLLPVT	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.7068
p.V350F	NCI-H358	lung	COSMIC	ARKHLLPVT	DEG_APCC_DBOX_1	343:351	Mutation altering degron motif	0.7068
p.D338V	SIDM00541	Colorectal Carcinoma	GDSC	ARKHLLPVT	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.1944
p.D338V	ACH-000926	Colon/Colorectal Cancer	CCLE	ARKHLLPVT	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.1944
p.D338V	HT55	large intestine	COSMIC	ARKHLLPVT	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.1944
p.T335N	SIDM00951	T-Lymphoblastic Leukemia	GDSC	ARKHLLPVT	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.1111
p.T335N	CTV-1	haematopoietic and lymphoid tissue	COSMIC	ARKHLLPVT	DEG_APCC_DBOX_1	343:351	Mutation rewiring degron network	0.1111
p.K334N	SIDM01612	Endometrial Carcinoma	GDSC	ARKHLLPVT	DEG_APCC_DBOX_1	343:351	Mutation substituting flanking lysine	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC35E1

UniProt ID: Q96K37

Entrez ID: 79939

Protein name: Solute carrier family 35 member E1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC35E1 in