DegronMD

Uniprot ID: Q96K37

Source protein: Solute carrier family 35 member E1

Source gene: SLC35E1

Class: DEG_APCC_DBOX_1

Location: 343:351

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9799

ASA_SCORE: 103.4333

COIL: 0.6511

CONS_SCORE: 0.3128

DSS_SCORE: 0.4487

HELIX: 0.2899

FCONS_SCORE: 1.0339

RIG_SCORE: 0.7855

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R360H	TCGA-A5-A0VP	UCEC	TCGA	ARKHLLPVT	DEG_APCC_DBOX_1	0.0833
p.R360H	TCGA-AA-3695	COAD	TCGA	ARKHLLPVT	DEG_APCC_DBOX_1	0.0833
p.R360H	DO7166	CLLE	ICGC	ARKHLLPVT	DEG_APCC_DBOX_1	0.0833
p.R360H	DO10694	COAD	ICGC	ARKHLLPVT	DEG_APCC_DBOX_1	0.0833
p.R360H	DO42600	UCEC	ICGC	ARKHLLPVT	DEG_APCC_DBOX_1	0.0833
p.A339T	TCGA-AX-A06F	UCEC	TCGA	ARKHLLPVT	DEG_APCC_DBOX_1	0.2222
p.A339T	DO41752	UCEC	ICGC	ARKHLLPVT	DEG_APCC_DBOX_1	0.2222
p.V350I	TCGA-EO-A3KX	UCEC	TCGA	ARKHLLPVT	DEG_APCC_DBOX_1	0.5965
p.V350I	DO219774	UCEC	ICGC	ARKHLLPVT	DEG_APCC_DBOX_1	0.5965
p.Q341K	DO228952	LICA	ICGC	ARKHLLPVT	DEG_APCC_DBOX_1	0.2778
p.H346N	DO229009	LICA	ICGC	ARKHLLPVT	DEG_APCC_DBOX_1	0.6312
p.R360C	SIDM00789	Colorectal Carcinoma	GDSC	ARKHLLPVT	DEG_APCC_DBOX_1	0.0833
p.R360C	SIDM00145	T-Lymphoblastic Leukemia	GDSC	ARKHLLPVT	DEG_APCC_DBOX_1	0.0833
p.R360C	ACH-000997	Colon/Colorectal Cancer	CCLE	ARKHLLPVT	DEG_APCC_DBOX_1	0.0833
p.R360C	ACH-001127	Leukemia	CCLE	ARKHLLPVT	DEG_APCC_DBOX_1	0.0833
p.R360C	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	ARKHLLPVT	DEG_APCC_DBOX_1	0.0833
p.R360C	HCT-15	large_intestine	COSMIC	ARKHLLPVT	DEG_APCC_DBOX_1	0.0833
p.V350F	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	ARKHLLPVT	DEG_APCC_DBOX_1	0.7068
p.V350F	ACH-000860	Lung Cancer	CCLE	ARKHLLPVT	DEG_APCC_DBOX_1	0.7068
p.V350F	NCI-H358	lung	COSMIC	ARKHLLPVT	DEG_APCC_DBOX_1	0.7068
p.D338V	SIDM00541	Colorectal Carcinoma	GDSC	ARKHLLPVT	DEG_APCC_DBOX_1	0.1944
p.D338V	ACH-000926	Colon/Colorectal Cancer	CCLE	ARKHLLPVT	DEG_APCC_DBOX_1	0.1944
p.D338V	HT55	large_intestine	COSMIC	ARKHLLPVT	DEG_APCC_DBOX_1	0.1944
p.T335N	SIDM00951	T-Lymphoblastic Leukemia	GDSC	ARKHLLPVT	DEG_APCC_DBOX_1	0.1111
p.T335N	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	ARKHLLPVT	DEG_APCC_DBOX_1	0.1111
p.K334N	SIDM01612	Endometrial Carcinoma	GDSC	ARKHLLPVT	DEG_APCC_DBOX_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARKHLLPVT

Degron related mutations and impact score

Drug responses associated with SLC35E1 mutations

All proteins holding degron of ARKHLLPVT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96K37	Solute carrier family 35 member E1	DEG_APCC_DBOX_1	343:351	ARKHLLPVT	APC,CDC20,FZR1	0.9799	More...