DegronMD - Q96K80(ZC3H10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V181A	TCGA-CD-A4MJ	STAD	TCGA	RRHDLYDIY	DEG_APCC_DBOX_1	185:193	Mutation rewiring degron network	0.2222
p.V181A	DO47811	STAD	ICGC	RRHDLYDIY	DEG_APCC_DBOX_1	185:193	Mutation rewiring degron network	0.2222
p.R186H	TCGA-XK-AAIW	PRAD	TCGA	RRHDLYDIY	DEG_APCC_DBOX_1	185:193	Mutation altering degron motif	0.8244
p.R186H	DO51407	PRAD	ICGC	RRHDLYDIY	DEG_APCC_DBOX_1	185:193	Mutation altering degron motif	0.8244
p.E201K	DO48424	BLCA	ICGC	RRHDLYDIY	DEG_APCC_DBOX_1	185:193	Mutation rewiring degron network	0.1111
p.R186L	DO228974	LICA	ICGC	RRHDLYDIY	DEG_APCC_DBOX_1	185:193	Mutation altering degron motif	0.8428
p.G179V	DO229015	LICA	ICGC	RRHDLYDIY	DEG_APCC_DBOX_1	185:193	Mutation rewiring degron network	0.1667
p.P183T	SIDM00962	Chronic Myelogenous Leukemia	GDSC	RRHDLYDIY	DEG_APCC_DBOX_1	185:193	Mutation rewiring degron network	0.2778
p.P183T	ACH-000432	Leukemia	CCLE	RRHDLYDIY	DEG_APCC_DBOX_1	185:193	Mutation rewiring degron network	0.2778
p.P183T	BV-173	haematopoietic and lymphoid tissue	COSMIC	RRHDLYDIY	DEG_APCC_DBOX_1	185:193	Mutation rewiring degron network	0.2778
p.D197E	SIDM00529	Breast Carcinoma	GDSC	RRHDLYDIY	DEG_APCC_DBOX_1	185:193	Mutation rewiring degron network	0.2222
p.D197E	ACH-000621	Breast Cancer	CCLE	RRHDLYDIY	DEG_APCC_DBOX_1	185:193	Mutation rewiring degron network	0.2222
p.D197E	MDA-MB-157	breast	COSMIC	RRHDLYDIY	DEG_APCC_DBOX_1	185:193	Mutation rewiring degron network	0.2222
p.R185Q	SIDM01113	Other Sarcomas	GDSC	RRHDLYDIY	DEG_APCC_DBOX_1	185:193	Mutation altering degron motif	0.6218
p.R185Q	ACH-000939	Sarcoma	CCLE	RRHDLYDIY	DEG_APCC_DBOX_1	185:193	Mutation altering degron motif	0.6218
p.R185Q	SK-UT-1	soft tissue	COSMIC	RRHDLYDIY	DEG_APCC_DBOX_1	185:193	Mutation altering degron motif	0.6218

Kaplan plot for ZC3H10 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZC3H10

UniProt ID: Q96K80

Entrez ID: 84872

Protein name: Zinc finger CCCH domain-containing protein 10

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZC3H10 in