DegronMD

Uniprot ID: Q96K80

Source protein: Zinc finger CCCH domain-containing protein 10

Source gene: ZC3H10

Class: DEG_APCC_DBOX_1

Location: 185:193

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9925

ASA_SCORE: 80.8556

COIL: 0.7533

CONS_SCORE: 0.2939

DSS_SCORE: 0.4756

HELIX: 0.1653

FCONS_SCORE: 0.7541

RIG_SCORE: 0.7915

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V181A	TCGA-CD-A4MJ	STAD	TCGA	RRHDLYDIY	DEG_APCC_DBOX_1	0.2222
p.V181A	DO47811	STAD	ICGC	RRHDLYDIY	DEG_APCC_DBOX_1	0.2222
p.R186H	TCGA-XK-AAIW	PRAD	TCGA	RRHDLYDIY	DEG_APCC_DBOX_1	0.8244
p.R186H	DO51407	PRAD	ICGC	RRHDLYDIY	DEG_APCC_DBOX_1	0.8244
p.E201K	DO48424	BLCA	ICGC	RRHDLYDIY	DEG_APCC_DBOX_1	0.1111
p.R186L	DO228974	LICA	ICGC	RRHDLYDIY	DEG_APCC_DBOX_1	0.8428
p.G179V	DO229015	LICA	ICGC	RRHDLYDIY	DEG_APCC_DBOX_1	0.1667
p.P183T	SIDM00962	Chronic Myelogenous Leukemia	GDSC	RRHDLYDIY	DEG_APCC_DBOX_1	0.2778
p.P183T	ACH-000432	Leukemia	CCLE	RRHDLYDIY	DEG_APCC_DBOX_1	0.2778
p.P183T	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	RRHDLYDIY	DEG_APCC_DBOX_1	0.2778
p.D197E	SIDM00529	Breast Carcinoma	GDSC	RRHDLYDIY	DEG_APCC_DBOX_1	0.2222
p.D197E	ACH-000621	Breast Cancer	CCLE	RRHDLYDIY	DEG_APCC_DBOX_1	0.2222
p.D197E	MDA-MB-157	breast	COSMIC	RRHDLYDIY	DEG_APCC_DBOX_1	0.2222
p.R185Q	SIDM01113	Other Sarcomas	GDSC	RRHDLYDIY	DEG_APCC_DBOX_1	0.6218
p.R185Q	ACH-000939	Sarcoma	CCLE	RRHDLYDIY	DEG_APCC_DBOX_1	0.6218
p.R185Q	SK-UT-1	soft_tissue	COSMIC	RRHDLYDIY	DEG_APCC_DBOX_1	0.6218

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96K80	Zinc finger CCCH domain-containing protein 10	DEG_APCC_DBOX_1	185:193	RRHDLYDIY	APC,CDC20,FZR1	0.9925	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons