DegronMD - Q96KC9(CABS1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E16K	TCGA-DA-A95Z	SKCM	TCGA	DGLPKIYSHPP	CBL_PTK	4:14	Mutation rewiring degron network	0.2778
p.E16K	DO229446	SKCA	ICGC	DGLPKIYSHPP	CBL_PTK	4:14	Mutation rewiring degron network	0.2778
p.E16K	DO219481	SKCM	ICGC	DGLPKIYSHPP	CBL_PTK	4:14	Mutation rewiring degron network	0.2778
p.D4N	TCGA-G4-6309	COAD	TCGA	DGLPKIYSHPP	CBL_PTK	4:14	Mutation altering degron motif	0.5821
p.D4N	DO7810	COAD	ICGC	DGLPKIYSHPP	CBL_PTK	4:14	Mutation altering degron motif	0.5821
p.T22I	DO52450	COCA	ICGC	DGLPKIYSHPP	CBL_PTK	4:14	Mutation rewiring degron network	0.1111
p.P21T	DO18392	KIRC	ICGC	DGLPKIYSHPP	CBL_PTK	4:14	Mutation rewiring degron network	0.1389
p.S18G	DO231726	LINC	ICGC	DGLPKIYSHPP	CBL_PTK	4:14	Mutation rewiring degron network	0.2222
p.T20R	DO23348	LINC	ICGC	DGLPKIYSHPP	CBL_PTK	4:14	Mutation rewiring degron network	0.1667
p.S17C	DO45273	LIRI	ICGC	DGLPKIYSHPP	CBL_PTK	4:14	Mutation rewiring degron network	0.25
p.G5S	DO222749	MELA	ICGC	DGLPKIYSHPP	CBL_PTK	4:14	Mutation altering degron motif	0.5882
p.P21Q	SIDM01951	Colorectal Carcinoma	GDSC	DGLPKIYSHPP	CBL_PTK	4:14	Mutation rewiring degron network	0.1389
p.T15A	SIDM00915	Small Cell Lung Carcinoma	GDSC	DGLPKIYSHPP	CBL_PTK	4:14	Mutation rewiring degron network	0.3056
p.T15A	SIDM01117	Small Cell Lung Carcinoma	GDSC	DGLPKIYSHPP	CBL_PTK	4:14	Mutation rewiring degron network	0.3056
p.T15A	SIDM00656	Burkitt's Lymphoma	GDSC	DGLPKIYSHPP	CBL_PTK	4:14	Mutation rewiring degron network	0.3056
p.T15A	SIDM00633	Breast Carcinoma	GDSC	DGLPKIYSHPP	CBL_PTK	4:14	Mutation rewiring degron network	0.3056
p.T15A	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	DGLPKIYSHPP	CBL_PTK	4:14	Mutation rewiring degron network	0.3056
p.T15A	SIDM01120	Other Solid Cancers	GDSC	DGLPKIYSHPP	CBL_PTK	4:14	Mutation rewiring degron network	0.3056
p.T15A	SIDM00844	Burkitt's Lymphoma	GDSC	DGLPKIYSHPP	CBL_PTK	4:14	Mutation rewiring degron network	0.3056
p.T15A	SIDM00539	Esophageal Carcinoma	GDSC	DGLPKIYSHPP	CBL_PTK	4:14	Mutation rewiring degron network	0.3056
p.T15A	SIDM00954	Breast Carcinoma	GDSC	DGLPKIYSHPP	CBL_PTK	4:14	Mutation rewiring degron network	0.3056
p.T15A	SIDM01173	Rhabdomyosarcoma	GDSC	DGLPKIYSHPP	CBL_PTK	4:14	Mutation rewiring degron network	0.3056
p.T15A	SIDM00641	Burkitt's Lymphoma	GDSC	DGLPKIYSHPP	CBL_PTK	4:14	Mutation rewiring degron network	0.3056
p.T15A	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	DGLPKIYSHPP	CBL_PTK	4:14	Mutation rewiring degron network	0.3056
p.H12Y	SIDM00304	Ovarian Carcinoma	GDSC	DGLPKIYSHPP	CBL_PTK	4:14	Mutation altering degron motif	0.6118
p.H12Y	ACH-002146	Ovarian Cancer	CCLE	DGLPKIYSHPP	CBL_PTK	4:14	Mutation altering degron motif	0.6118
p.H12Y	JHOS-3	ovary	COSMIC	DGLPKIYSHPP	CBL_PTK	4:14	Mutation altering degron motif	0.6118

Kaplan plot for CABS1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CABS1

UniProt ID: Q96KC9

Entrez ID: 85438

Protein name: Calcium-binding and spermatid-specific protein 1 (Testis development protein NYD-SP26)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CABS1 in