DegronMD

Uniprot ID: Q96KC9

Source protein: Calcium-binding and spermatid-specific protein 1

Source gene: CABS1

Class: CBL_PTK

Location: 4:14

E3 ligase: CBL

DEGRON score: 0.9971

ASA_SCORE: 80.4636

COIL: 0.8543

CONS_SCORE: 0.9268

DSS_SCORE: 0.7037

HELIX: 0.0209

FCONS_SCORE: 1.136

RIG_SCORE: 0.672

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E16K	TCGA-DA-A95Z	SKCM	TCGA	DGLPKIYSHPP	CBL_PTK	0.2778
p.E16K	DO229446	SKCA	ICGC	DGLPKIYSHPP	CBL_PTK	0.2778
p.E16K	DO219481	SKCM	ICGC	DGLPKIYSHPP	CBL_PTK	0.2778
p.D4N	TCGA-G4-6309	COAD	TCGA	DGLPKIYSHPP	CBL_PTK	0.5821
p.D4N	DO7810	COAD	ICGC	DGLPKIYSHPP	CBL_PTK	0.5821
p.T22I	DO52450	COCA	ICGC	DGLPKIYSHPP	CBL_PTK	0.1111
p.P21T	DO18392	KIRC	ICGC	DGLPKIYSHPP	CBL_PTK	0.1389
p.S18G	DO231726	LINC	ICGC	DGLPKIYSHPP	CBL_PTK	0.2222
p.T20R	DO23348	LINC	ICGC	DGLPKIYSHPP	CBL_PTK	0.1667
p.S17C	DO45273	LIRI	ICGC	DGLPKIYSHPP	CBL_PTK	0.25
p.G5S	DO222749	MELA	ICGC	DGLPKIYSHPP	CBL_PTK	0.5882
p.P21Q	SIDM01951	Colorectal Carcinoma	GDSC	DGLPKIYSHPP	CBL_PTK	0.1389
p.T15A	SIDM00915	Small Cell Lung Carcinoma	GDSC	DGLPKIYSHPP	CBL_PTK	0.3056
p.T15A	SIDM01117	Small Cell Lung Carcinoma	GDSC	DGLPKIYSHPP	CBL_PTK	0.3056
p.T15A	SIDM00656	Burkitt's Lymphoma	GDSC	DGLPKIYSHPP	CBL_PTK	0.3056
p.T15A	SIDM00633	Breast Carcinoma	GDSC	DGLPKIYSHPP	CBL_PTK	0.3056
p.T15A	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	DGLPKIYSHPP	CBL_PTK	0.3056
p.T15A	SIDM01120	Other Solid Cancers	GDSC	DGLPKIYSHPP	CBL_PTK	0.3056
p.T15A	SIDM00844	Burkitt's Lymphoma	GDSC	DGLPKIYSHPP	CBL_PTK	0.3056
p.T15A	SIDM00539	Esophageal Carcinoma	GDSC	DGLPKIYSHPP	CBL_PTK	0.3056
p.T15A	SIDM00954	Breast Carcinoma	GDSC	DGLPKIYSHPP	CBL_PTK	0.3056
p.T15A	SIDM01173	Rhabdomyosarcoma	GDSC	DGLPKIYSHPP	CBL_PTK	0.3056
p.T15A	SIDM00641	Burkitt's Lymphoma	GDSC	DGLPKIYSHPP	CBL_PTK	0.3056
p.T15A	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	DGLPKIYSHPP	CBL_PTK	0.3056
p.H12Y	SIDM00304	Ovarian Carcinoma	GDSC	DGLPKIYSHPP	CBL_PTK	0.6118
p.H12Y	ACH-002146	Ovarian Cancer	CCLE	DGLPKIYSHPP	CBL_PTK	0.6118
p.H12Y	JHOS-3	ovary	COSMIC	DGLPKIYSHPP	CBL_PTK	0.6118

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96KC9	Calcium-binding and spermatid-specific protein 1	CBL_PTK	4:14	DGLPKIYSHPP	CBL	0.9971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DGLPKIYSHPP

Degron related mutations and impact score

Drug responses associated with CABS1 mutations

All proteins holding degron of DGLPKIYSHPP