DegronMD - Q96KG9(SCYL1)

SCYL1

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P619H	TCGA-61-2096	OV	TCGA	VPATPTTS	DEG_SCF_FBW7_1	615:622	Mutation altering degron motif	0.7694
p.P619H	DO29708	OV	ICGC	VPATPTTS	DEG_SCF_FBW7_1	615:622	Mutation altering degron motif	0.7694
p.E605K	TCGA-CV-5436	HNSC	TCGA	VPATPTTS	DEG_SCF_FBW7_1	615:622	Mutation rewiring degron network	0.0556
p.E605K	DO15006	HNSC	ICGC	VPATPTTS	DEG_SCF_FBW7_1	615:622	Mutation rewiring degron network	0.0556
p.P610T	TCGA-D3-A2JH	SKCM	TCGA	VPATPTTS	DEG_SCF_FBW7_1	615:622	Mutation rewiring degron network	0.1944
p.P610T	DO47263	SKCM	ICGC	VPATPTTS	DEG_SCF_FBW7_1	615:622	Mutation rewiring degron network	0.1944
p.G623R	TCGA-FW-A3TU	SKCM	TCGA	VPATPTTS	DEG_SCF_FBW7_1	615:622	Mutation rewiring degron network	0.3056
p.P616S	TCGA-GN-A8LK	SKCM	TCGA	VPATPTTS	DEG_SCF_FBW7_1	615:622	Mutation altering degron motif	0.5641
p.P616S	DO51259	SKCM	ICGC	VPATPTTS	DEG_SCF_FBW7_1	615:622	Mutation altering degron motif	0.5641
p.T613P	DO228029	EOPC	ICGC	VPATPTTS	DEG_SCF_FBW7_1	615:622	Mutation rewiring degron network	0.2778
p.P612H	ACH-002265	Head and Neck Cancer	CCLE	VPATPTTS	DEG_SCF_FBW7_1	615:622	Mutation rewiring degron network	0.25
p.P612H	LB771-HNC	upper aerodigestive tract	COSMIC	VPATPTTS	DEG_SCF_FBW7_1	615:622	Mutation rewiring degron network	0.25
p.E621D	FLO-1	oesophagus	COSMIC	VPATPTTS	DEG_SCF_FBW7_1	615:622	Mutation altering degron motif	0.6758

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*NOTE: the Kaplan plots were collected from OncoLnc