DegronMD

Uniprot ID: Q96KG9

Source protein: N-terminal kinase-like protein

Source gene: SCYL1

Class: DEG_SCF_FBW7_1

Location: 615:622

E3 ligase: FBXW7

DEGRON score: 0.8705

ASA_SCORE: 84.225

COIL: 0.9355

CONS_SCORE: 0.3013

DSS_SCORE: 0.8164

HELIX: 0.0305

FCONS_SCORE: 1.007

RIG_SCORE: 0.5763

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P619H	TCGA-61-2096	OV	TCGA	VPATPTTS	DEG_SCF_FBW7_1	0.7694
p.P619H	DO29708	OV	ICGC	VPATPTTS	DEG_SCF_FBW7_1	0.7694
p.E605K	TCGA-CV-5436	HNSC	TCGA	VPATPTTS	DEG_SCF_FBW7_1	0.0556
p.E605K	DO15006	HNSC	ICGC	VPATPTTS	DEG_SCF_FBW7_1	0.0556
p.P610T	TCGA-D3-A2JH	SKCM	TCGA	VPATPTTS	DEG_SCF_FBW7_1	0.1944
p.P610T	DO47263	SKCM	ICGC	VPATPTTS	DEG_SCF_FBW7_1	0.1944
p.G623R	TCGA-FW-A3TU	SKCM	TCGA	VPATPTTS	DEG_SCF_FBW7_1	0.3056
p.P616S	TCGA-GN-A8LK	SKCM	TCGA	VPATPTTS	DEG_SCF_FBW7_1	0.5641
p.P616S	DO51259	SKCM	ICGC	VPATPTTS	DEG_SCF_FBW7_1	0.5641
p.T613P	DO228029	EOPC	ICGC	VPATPTTS	DEG_SCF_FBW7_1	0.2778
p.P612H	ACH-002265	Head and Neck Cancer	CCLE	VPATPTTS	DEG_SCF_FBW7_1	0.25
p.P612H	LB771-HNC	upper_aerodigestive_tract	COSMIC	VPATPTTS	DEG_SCF_FBW7_1	0.25
p.E621D	FLO-1	oesophagus	COSMIC	VPATPTTS	DEG_SCF_FBW7_1	0.6758

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96KG9	N-terminal kinase-like protein	DEG_SCF_FBW7_1	615:622	VPATPTTS	FBXW7	0.8705	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons