DegronMD - Q96KV7(WDR90)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P271Q	TCGA-CD-A4MJ	STAD	TCGA	VVQTPSPT	DEG_SCF_FBW7_1	272:279	Mutation rewiring degron network	0.3056
p.P271Q	DO47811	STAD	ICGC	VVQTPSPT	DEG_SCF_FBW7_1	272:279	Mutation rewiring degron network	0.3056
p.R266W	TCGA-D7-6518	STAD	TCGA	VVQTPSPT	DEG_SCF_FBW7_1	272:279	Mutation rewiring degron network	0.1667
p.R266W	DO38519	STAD	ICGC	VVQTPSPT	DEG_SCF_FBW7_1	272:279	Mutation rewiring degron network	0.1667
p.R266W	SIDM00217	Colorectal Carcinoma	GDSC	VVQTPSPT	DEG_SCF_FBW7_1	272:279	Mutation rewiring degron network	0.1667
p.R266W	SNU-1040	large intestine	COSMIC	VVQTPSPT	DEG_SCF_FBW7_1	272:279	Mutation rewiring degron network	0.1667
p.P288S	TCGA-GF-A6C8	SKCM	TCGA	VVQTPSPT	DEG_SCF_FBW7_1	272:279	Mutation rewiring degron network	0.0833
p.P288S	DO48765	SKCM	ICGC	VVQTPSPT	DEG_SCF_FBW7_1	272:279	Mutation rewiring degron network	0.0833
p.R283L	TCGA-GN-A26D	SKCM	TCGA	VVQTPSPT	DEG_SCF_FBW7_1	272:279	Mutation rewiring degron network	0.2222
p.R283L	DO37480	SKCM	ICGC	VVQTPSPT	DEG_SCF_FBW7_1	272:279	Mutation rewiring degron network	0.2222
p.A280V	TCGA-QC-A7B5	SARC	TCGA	VVQTPSPT	DEG_SCF_FBW7_1	272:279	Mutation rewiring degron network	0.3056
p.A280V	DO220239	SARC	ICGC	VVQTPSPT	DEG_SCF_FBW7_1	272:279	Mutation rewiring degron network	0.3056
p.S277I	DO229038	LICA	ICGC	VVQTPSPT	DEG_SCF_FBW7_1	272:279	Mutation altering degron motif	0.7341
p.L286M	DO229216	THCA	ICGC	VVQTPSPT	DEG_SCF_FBW7_1	272:279	Mutation rewiring degron network	0.1389
p.V265L	SIDM00095	Glioblastoma	GDSC	VVQTPSPT	DEG_SCF_FBW7_1	272:279	Mutation rewiring degron network	0.1389
p.V265L	ACH-000504	Brain Cancer	CCLE	VVQTPSPT	DEG_SCF_FBW7_1	272:279	Mutation rewiring degron network	0.1389
p.V265L	SNB75	central nervous system	COSMIC	VVQTPSPT	DEG_SCF_FBW7_1	272:279	Mutation rewiring degron network	0.1389
p.T275M	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	VVQTPSPT	DEG_SCF_FBW7_1	272:279	Mutation altering degron motif	0.8534
p.T275M	SIDM01173	Rhabdomyosarcoma	GDSC	VVQTPSPT	DEG_SCF_FBW7_1	272:279	Mutation altering degron motif	0.8534
p.A285T	SIDM00077	Oral Cavity Carcinoma	GDSC	VVQTPSPT	DEG_SCF_FBW7_1	272:279	Mutation rewiring degron network	0.1667
p.A285T	BICR10	upper aerodigestive tract	COSMIC	VVQTPSPT	DEG_SCF_FBW7_1	272:279	Mutation rewiring degron network	0.1667
p.M279T	GP5d	large intestine	COSMIC	VVQTPSPT	DEG_SCF_FBW7_1	272:279	Mutation altering degron motif	0.7423
p.R275K	MFE-319	endometrium	COSMIC	VVQTPSPT	DEG_SCF_FBW7_1	272:279	Mutation altering degron motif	0.7237

Kaplan plot for WDR90 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WDR90

UniProt ID: Q96KV7

Entrez ID: 197335

Protein name: WD repeat-containing protein 90

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for WDR90 in