DegronMD

Uniprot ID: Q96KV7

Source protein: WD repeat-containing protein 90

Source gene: WDR90

Class: DEG_SCF_FBW7_1

Location: 272:279

E3 ligase: FBXW7

DEGRON score: 0.9728

ASA_SCORE: 73.9625

COIL: 0.6789

CONS_SCORE: 0.2724

DSS_SCORE: 0.4916

HELIX: 0.0245

FCONS_SCORE: 0.9128

RIG_SCORE: 0.6516

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P271Q	TCGA-CD-A4MJ	STAD	TCGA	VVQTPSPT	DEG_SCF_FBW7_1	0.3056
p.P271Q	DO47811	STAD	ICGC	VVQTPSPT	DEG_SCF_FBW7_1	0.3056
p.R266W	TCGA-D7-6518	STAD	TCGA	VVQTPSPT	DEG_SCF_FBW7_1	0.1667
p.R266W	DO38519	STAD	ICGC	VVQTPSPT	DEG_SCF_FBW7_1	0.1667
p.R266W	SIDM00217	Colorectal Carcinoma	GDSC	VVQTPSPT	DEG_SCF_FBW7_1	0.1667
p.R266W	SNU-1040	large_intestine	COSMIC	VVQTPSPT	DEG_SCF_FBW7_1	0.1667
p.P288S	TCGA-GF-A6C8	SKCM	TCGA	VVQTPSPT	DEG_SCF_FBW7_1	0.0833
p.P288S	DO48765	SKCM	ICGC	VVQTPSPT	DEG_SCF_FBW7_1	0.0833
p.R283L	TCGA-GN-A26D	SKCM	TCGA	VVQTPSPT	DEG_SCF_FBW7_1	0.2222
p.R283L	DO37480	SKCM	ICGC	VVQTPSPT	DEG_SCF_FBW7_1	0.2222
p.A280V	TCGA-QC-A7B5	SARC	TCGA	VVQTPSPT	DEG_SCF_FBW7_1	0.3056
p.A280V	DO220239	SARC	ICGC	VVQTPSPT	DEG_SCF_FBW7_1	0.3056
p.S277I	DO229038	LICA	ICGC	VVQTPSPT	DEG_SCF_FBW7_1	0.7341
p.L286M	DO229216	THCA	ICGC	VVQTPSPT	DEG_SCF_FBW7_1	0.1389
p.V265L	SIDM00095	Glioblastoma	GDSC	VVQTPSPT	DEG_SCF_FBW7_1	0.1389
p.V265L	ACH-000504	Brain Cancer	CCLE	VVQTPSPT	DEG_SCF_FBW7_1	0.1389
p.V265L	SNB75	central_nervous_system	COSMIC	VVQTPSPT	DEG_SCF_FBW7_1	0.1389
p.T275M	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	VVQTPSPT	DEG_SCF_FBW7_1	0.8534
p.T275M	SIDM01173	Rhabdomyosarcoma	GDSC	VVQTPSPT	DEG_SCF_FBW7_1	0.8534
p.A285T	SIDM00077	Oral Cavity Carcinoma	GDSC	VVQTPSPT	DEG_SCF_FBW7_1	0.1667
p.A285T	BICR10	upper_aerodigestive_tract	COSMIC	VVQTPSPT	DEG_SCF_FBW7_1	0.1667
p.M279T	GP5d	large_intestine	COSMIC	VVQTPSPT	DEG_SCF_FBW7_1	0.7423
p.R275K	MFE-319	endometrium	COSMIC	VVQTPSPT	DEG_SCF_FBW7_1	0.7237

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96KV7	WD repeat-containing protein 90	DEG_SCF_FBW7_1	272:279	VVQTPSPT	FBXW7	0.9728	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons