DegronMD - Q96LA6(FCRL1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P342Q	TCGA-37-3789	LUSC	TCGA	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.5924
p.P342Q	DO26743	LUSC	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.5924
p.I334M	TCGA-86-A4JF	LUAD	TCGA	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.1944
p.I334M	DO45317	LUAD	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.1944
p.E353V	TCGA-A5-A0G1	UCEC	TCGA	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.1667
p.E353V	DO42472	UCEC	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.1667
p.R337H	TCGA-AX-A2HA	UCEC	TCGA	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.2778
p.R337H	DO42504	UCEC	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.2778
p.R340S	TCGA-D3-A2JG	SKCM	TCGA	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.7427
p.R340S	TCGA-EE-A2GN	SKCM	TCGA	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.7427
p.R340S	DO37896	SKCM	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.7427
p.R340S	DO47613	SKCM	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.7427
p.R340M	TCGA-DA-A1I7	SKCM	TCGA	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.8632
p.R340M	DO37951	SKCM	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.8632
p.R340M	SIDM00096	T-Cell Non-Hodgkin's Lymphoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.8632
p.R340M	ACH-000338	Lymphoma	CCLE	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.8632
p.R340M	SR	haematopoietic and lymphoid tissue	COSMIC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.8632
p.E353Q	TCGA-E1-A7YE	LGG	TCGA	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.1667
p.E353Q	DO223667	LGG	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.1667
p.L346H	TCGA-EE-A2GR	SKCM	TCGA	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.7313
p.L346H	DO37996	SKCM	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.7313
p.E353K	TCGA-EE-A3J7	SKCM	TCGA	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.1667
p.E353K	DO48770	SKCM	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.1667
p.R332K	TCGA-ER-A2NH	SKCM	TCGA	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.1389
p.R332K	DO47683	SKCM	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.1389
p.Q352K	TCGA-G3-A5SL	LIHC	TCGA	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.1944
p.Q352K	DO44978	LIHC	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.1944
p.G329D	TCGA-IB-7651	PAAD	TCGA	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.0556
p.G329D	DO46657	PAAD	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.0556
p.G343D	DO4928	BRCA	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.7198
p.G343D	DO10244	COAD	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.7198
p.G329S	DO50334	ESAD	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.0556
p.G329S	SIDM00216	Colorectal Carcinoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.0556
p.E350D	DO233163	GACA	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.25
p.Q351K	DO11166	GBM	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.2222
p.Q351K	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.2222
p.Q351K	NCI-H1299	lung	COSMIC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.2222
p.S348F	DO11854	GBM	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.3056
p.Q345L	DO219552	LIHC	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.7765
p.L357P	DO231910	LINC	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.0556
p.H342N	DO27200	LUSC	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.7423
p.D341N	DO220899	MELA	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.5821
p.P351L	DO222402	MELA	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.2222
p.P342L	DO222662	MELA	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.6471
p.R344T	DO29026	OV	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.6765
p.E333D	DO51294	SKCM	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation substituting flanking lysine	0.2778
p.A339S	DO229211	THCA	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.6477
p.S338A	DO41331	UCEC	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.3056
p.P351T	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.2222
p.P351T	SIDM00773	Non-Cancerous	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.2222
p.P351T	SIDM00849	Kidney Carcinoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.2222
p.P351T	SIDM00863	Burkitt's Lymphoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.2222
p.P351T	SIDM00774	Breast Carcinoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.2222
p.P351T	SIDM00808	Burkitt's Lymphoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.2222
p.P351T	SIDM01254	Burkitt's Lymphoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.2222
p.S345R	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.6316
p.K352R	SIDM00120	Prostate Carcinoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.1944
p.K352R	DU-145	prostate	COSMIC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.1944
p.H342Y	SIDM01123	Prostate Carcinoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.7229
p.H342Y	NCI-H660	prostate	COSMIC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.7229
p.Q337K	SIDM00881	Breast Carcinoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.2778
p.R337C	SIDM00251	Gastric Carcinoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.2778
p.R337C	ACH-000949	Gastric Cancer	CCLE	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.2778
p.R337C	TGBC11TKB	stomach	COSMIC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.2778
p.L346F	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.6981
p.L346F	ACH-000747	Lung Cancer	CCLE	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.6981
p.L346F	NCI-H1703	lung	COSMIC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.6981
p.R332I	SIDM01611	Endometrial Carcinoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.1389
p.R332I	ACH-000996	Endometrial/Uterine Cancer	CCLE	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation rewiring degron network	0.1389
p.P342T	ACH-000870	Lung Cancer	CCLE	ARDPLRSLP	DEG_APCC_DBOX_1	339:347	Mutation altering degron motif	0.5919

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FCRL1

UniProt ID: Q96LA6

Entrez ID: 115350

Protein name: Fc receptor-like protein 1 (FcR-like protein 1) (FcRL1) (Fc receptor homolog 1) (FcRH1) (IFGP family protein 1) (hIFGP1) (Immune receptor translocation-associated protein 5) (CD antigen CD307a)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FCRL1 in