DegronMD

Uniprot ID: Q96LA6

Source protein: Fc receptor-like protein 1

Source gene: FCRL1

Class: DEG_APCC_DBOX_1

Location: 339:347

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8174

ASA_SCORE: 101.7667

COIL: 0.9328

CONS_SCORE: 0.4889

DSS_SCORE: 0.4849

HELIX: 0.0301

FCONS_SCORE: 1.0854

RIG_SCORE: 0.6932

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P342Q	TCGA-37-3789	LUSC	TCGA	ARDPLRSLP	DEG_APCC_DBOX_1	0.5924
p.P342Q	DO26743	LUSC	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	0.5924
p.I334M	TCGA-86-A4JF	LUAD	TCGA	ARDPLRSLP	DEG_APCC_DBOX_1	0.1944
p.I334M	DO45317	LUAD	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	0.1944
p.E353V	TCGA-A5-A0G1	UCEC	TCGA	ARDPLRSLP	DEG_APCC_DBOX_1	0.1667
p.E353V	DO42472	UCEC	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	0.1667
p.R337H	TCGA-AX-A2HA	UCEC	TCGA	ARDPLRSLP	DEG_APCC_DBOX_1	0.2778
p.R337H	DO42504	UCEC	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	0.2778
p.R340S	TCGA-D3-A2JG	SKCM	TCGA	ARDPLRSLP	DEG_APCC_DBOX_1	0.7427
p.R340S	TCGA-EE-A2GN	SKCM	TCGA	ARDPLRSLP	DEG_APCC_DBOX_1	0.7427
p.R340S	DO37896	SKCM	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	0.7427
p.R340S	DO47613	SKCM	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	0.7427
p.R340M	TCGA-DA-A1I7	SKCM	TCGA	ARDPLRSLP	DEG_APCC_DBOX_1	0.8632
p.R340M	DO37951	SKCM	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	0.8632
p.R340M	SIDM00096	T-Cell Non-Hodgkin's Lymphoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	0.8632
p.R340M	ACH-000338	Lymphoma	CCLE	ARDPLRSLP	DEG_APCC_DBOX_1	0.8632
p.R340M	SR	haematopoietic_and_lymphoid_tissue	COSMIC	ARDPLRSLP	DEG_APCC_DBOX_1	0.8632
p.E353Q	TCGA-E1-A7YE	LGG	TCGA	ARDPLRSLP	DEG_APCC_DBOX_1	0.1667
p.E353Q	DO223667	LGG	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	0.1667
p.L346H	TCGA-EE-A2GR	SKCM	TCGA	ARDPLRSLP	DEG_APCC_DBOX_1	0.7313
p.L346H	DO37996	SKCM	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	0.7313
p.E353K	TCGA-EE-A3J7	SKCM	TCGA	ARDPLRSLP	DEG_APCC_DBOX_1	0.1667
p.E353K	DO48770	SKCM	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	0.1667
p.R332K	TCGA-ER-A2NH	SKCM	TCGA	ARDPLRSLP	DEG_APCC_DBOX_1	0.1389
p.R332K	DO47683	SKCM	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	0.1389
p.Q352K	TCGA-G3-A5SL	LIHC	TCGA	ARDPLRSLP	DEG_APCC_DBOX_1	0.1944
p.Q352K	DO44978	LIHC	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	0.1944
p.G329D	TCGA-IB-7651	PAAD	TCGA	ARDPLRSLP	DEG_APCC_DBOX_1	0.0556
p.G329D	DO46657	PAAD	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	0.0556
p.G343D	DO4928	BRCA	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	0.7198
p.G343D	DO10244	COAD	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	0.7198
p.G329S	DO50334	ESAD	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	0.0556
p.G329S	SIDM00216	Colorectal Carcinoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	0.0556
p.E350D	DO233163	GACA	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	0.25
p.Q351K	DO11166	GBM	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	0.2222
p.Q351K	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	0.2222
p.Q351K	NCI-H1299	lung	COSMIC	ARDPLRSLP	DEG_APCC_DBOX_1	0.2222
p.S348F	DO11854	GBM	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	0.3056
p.Q345L	DO219552	LIHC	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	0.7765
p.L357P	DO231910	LINC	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	0.0556
p.H342N	DO27200	LUSC	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	0.7423
p.D341N	DO220899	MELA	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	0.5821
p.P351L	DO222402	MELA	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	0.2222
p.P342L	DO222662	MELA	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	0.6471
p.R344T	DO29026	OV	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	0.6765
p.E333D	DO51294	SKCM	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	0.2778
p.A339S	DO229211	THCA	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	0.6477
p.S338A	DO41331	UCEC	ICGC	ARDPLRSLP	DEG_APCC_DBOX_1	0.3056
p.P351T	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	0.2222
p.P351T	SIDM00773	Non-Cancerous	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	0.2222
p.P351T	SIDM00849	Kidney Carcinoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	0.2222
p.P351T	SIDM00863	Burkitt's Lymphoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	0.2222
p.P351T	SIDM00774	Breast Carcinoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	0.2222
p.P351T	SIDM00808	Burkitt's Lymphoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	0.2222
p.P351T	SIDM01254	Burkitt's Lymphoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	0.2222
p.S345R	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	0.6316
p.K352R	SIDM00120	Prostate Carcinoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	0.1944
p.K352R	DU-145	prostate	COSMIC	ARDPLRSLP	DEG_APCC_DBOX_1	0.1944
p.H342Y	SIDM01123	Prostate Carcinoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	0.7229
p.H342Y	NCI-H660	prostate	COSMIC	ARDPLRSLP	DEG_APCC_DBOX_1	0.7229
p.Q337K	SIDM00881	Breast Carcinoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	0.2778
p.R337C	SIDM00251	Gastric Carcinoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	0.2778
p.R337C	ACH-000949	Gastric Cancer	CCLE	ARDPLRSLP	DEG_APCC_DBOX_1	0.2778
p.R337C	TGBC11TKB	stomach	COSMIC	ARDPLRSLP	DEG_APCC_DBOX_1	0.2778
p.L346F	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	0.6981
p.L346F	ACH-000747	Lung Cancer	CCLE	ARDPLRSLP	DEG_APCC_DBOX_1	0.6981
p.L346F	NCI-H1703	lung	COSMIC	ARDPLRSLP	DEG_APCC_DBOX_1	0.6981
p.R332I	SIDM01611	Endometrial Carcinoma	GDSC	ARDPLRSLP	DEG_APCC_DBOX_1	0.1389
p.R332I	ACH-000996	Endometrial/Uterine Cancer	CCLE	ARDPLRSLP	DEG_APCC_DBOX_1	0.1389
p.P342T	ACH-000870	Lung Cancer	CCLE	ARDPLRSLP	DEG_APCC_DBOX_1	0.5919

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARDPLRSLP

Degron related mutations and impact score

Drug responses associated with FCRL1 mutations

All proteins holding degron of ARDPLRSLP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96LA6	Fc receptor-like protein 1	DEG_APCC_DBOX_1	339:347	ARDPLRSLP	APC,CDC20,FZR1	0.8174	More...