DegronMD - Q96LU7(MYRFL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E698D	DO234313	ESAD	ICGC	TTPASLQVPEI	DEG_COP1_1	689:699	Mutation altering degron motif	0.5647
p.D42G	DO231949	LICA	ICGC	LPDTPPYS	DEG_SCF_FBW7_1	50:57	Mutation rewiring degron network	0.1111
p.D42Y	DO229037	LICA	ICGC	LPDTPPYS	DEG_SCF_FBW7_1	50:57	Mutation rewiring degron network	0.1111
p.P680L	DO44864	LICA	ICGC	TTPASLQVPEI	DEG_COP1_1	689:699	Mutation rewiring degron network	0.0833
p.P41L	DO220886	MELA	ICGC	LPDTPPYS	DEG_SCF_FBW7_1	50:57	Mutation rewiring degron network	0.0833
p.E709K	DO222702	MELA	ICGC	TTPASLQVPEI	DEG_COP1_1	689:699	Mutation rewiring degron network	0.0556
p.A681T	DO36556	READ	ICGC	TTPASLQVPEI	DEG_COP1_1	689:699	Mutation rewiring degron network	0.1111
p.P706L	SIDM00375	Head and Neck Carcinoma	GDSC	TTPASLQVPEI	DEG_COP1_1	689:699	Mutation rewiring degron network	0.1389
p.P706L	ACH-002305	Head and Neck Cancer	CCLE	TTPASLQVPEI	DEG_COP1_1	689:699	Mutation rewiring degron network	0.1389
p.P706L	SKN-3	upper aerodigestive tract	COSMIC	TTPASLQVPEI	DEG_COP1_1	689:699	Mutation rewiring degron network	0.1389
p.V696I	SIDM00801	Melanoma	GDSC	TTPASLQVPEI	DEG_COP1_1	689:699	Mutation altering degron motif	0.7076
p.V696I	ACH-000008	Skin Cancer	CCLE	TTPASLQVPEI	DEG_COP1_1	689:699	Mutation altering degron motif	0.7076
p.V696I	ACH-000014	Metastasis	CCLE	TTPASLQVPEI	DEG_COP1_1	689:699	Mutation altering degron motif	0.7076
p.V696I	A101D	skin	COSMIC	TTPASLQVPEI	DEG_COP1_1	689:699	Mutation altering degron motif	0.7076
p.S681L	ACH-000923	Lymphoma	CCLE	TTPASLQVPEI	DEG_COP1_1	689:699	Mutation rewiring degron network	0.1111
p.S681L	ACH-000975	Lung Cancer	CCLE	TTPASLQVPEI	DEG_COP1_1	689:699	Mutation rewiring degron network	0.1111
p.P706S	ACH-000982	Colon/Colorectal Cancer	CCLE	TTPASLQVPEI	DEG_COP1_1	689:699	Mutation rewiring degron network	0.1389
p.F701L	ACH-001685	Lymphoma	CCLE	TTPASLQVPEI	DEG_COP1_1	689:699	Mutation rewiring degron network	0.2778
p.V685I	A101D	skin	COSMIC	TTPASLQVPEI	DEG_COP1_1	689:699	Mutation rewiring degron network	0.2222
p.C702S	huH-1	liver	COSMIC	TTPASLQVPEI	DEG_COP1_1	689:699	Mutation rewiring degron network	0.25
p.P695L	SKN-3	upper aerodigestive tract	COSMIC	TTPASLQVPEI	DEG_COP1_1	689:699	Mutation altering degron motif	0.7582
p.V61I	A101D	skin	COSMIC	LPDTPPYS	DEG_SCF_FBW7_1	50:57	Mutation rewiring degron network	0.2222

Kaplan plot for MYRFL in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYRFL

UniProt ID: Q96LU7

Entrez ID: 196446

Protein name: Myelin regulatory factor-like protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYRFL in