DegronMD - Q96M02(C10orf90)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A545V	TCGA-AP-A1DK	UCEC	TCGA	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation rewiring degron network	0.1389
p.K522Q	TCGA-AP-A1DV	UCEC	TCGA	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation substituting flanking lysine	0.1667
p.D548N	TCGA-B5-A3FA	UCEC	TCGA	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation rewiring degron network	0.0556
p.T534A	TCGA-CG-5728	STAD	TCGA	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation altering degron motif	0.825
p.K524N	TCGA-E6-A1LX	UCEC	TCGA	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation substituting flanking lysine	0.2222
p.P542L	TCGA-W3-AA1V	SKCM	TCGA	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation rewiring degron network	0.2222
p.E530D	DO9346	COAD	ICGC	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation rewiring degron network	0.2778
p.E530D	DO234402	ESAD	ICGC	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation rewiring degron network	0.2778
p.E530D	DO233230	GACA	ICGC	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation rewiring degron network	0.2778
p.E530D	DO233291	GACA	ICGC	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation rewiring degron network	0.2778
p.E530D	DO51799	STAD	ICGC	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation rewiring degron network	0.2778
p.S538Y	DO7783	COAD	ICGC	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation altering degron motif	0.712
p.S538Y	DO26775	LUSC	ICGC	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation altering degron motif	0.712
p.S538Y	DO41584	UCEC	ICGC	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation altering degron motif	0.712
p.R532H	DO7862	COAD	ICGC	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation altering degron motif	0.8244
p.R532H	DO51545	PACA	ICGC	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation altering degron motif	0.8244
p.L544R	DO26455	LUSC	ICGC	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation rewiring degron network	0.1667
p.S540L	DO27927	ORCA	ICGC	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation rewiring degron network	0.2778
p.A528T	DO36317	PRAD	ICGC	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation substituting flanking lysine	0.3333
p.R539H	DO36531	READ	ICGC	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation rewiring degron network	0.3056
p.R539H	DO47940	STAD	ICGC	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation rewiring degron network	0.3056
p.S522Y	DO43578	UCEC	ICGC	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation substituting flanking lysine	0.1667
p.S522Y	DO43755	UCEC	ICGC	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation substituting flanking lysine	0.1667
p.S522Y	DO41133	UCEC	ICGC	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation substituting flanking lysine	0.1667
p.S522Y	DO43971	UCEC	ICGC	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation substituting flanking lysine	0.1667
p.R547H	SIDM00953	Small Cell Lung Carcinoma	GDSC	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation rewiring degron network	0.0833
p.A528P	ACH-000255	Gastric Cancer	CCLE	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation substituting flanking lysine	0.3333
p.R539C	ACH-000823	Esophageal Cancer	CCLE	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation rewiring degron network	0.3056
p.R539C	ACH-000994	Endometrial/Uterine Cancer	CCLE	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation rewiring degron network	0.3056
p.R532C	ACH-000999	Colon/Colorectal Cancer	CCLE	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation altering degron motif	0.8301
p.S522F	ACH-002926	Unknown	CCLE	PTTPEPS	DEG_SCF_FBW7_1	532:538	Mutation substituting flanking lysine	0.1667

Kaplan plot for C10orf90 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C10orf90

UniProt ID: Q96M02

Entrez ID: 118611

Protein name: (E2-independent) E3 ubiquitin-conjugating enzyme FATS (EC 2.3.2.-) (Centrosomal protein C10orf90) (E2/E3 hybrid ubiquitin-protein ligase FATS) (Fragile-site associated tumor suppressor homolog) (FATS)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C10orf90 in