DegronMD

Uniprot ID: Q96M02

Source protein:

Source gene: C10orf90

Class: DEG_SCF_FBW7_1

Location: 532:538

E3 ligase: FBXW7

DEGRON score: 0.6425

ASA_SCORE: 95.3857

COIL: 0.9647

CONS_SCORE: 0.5294

DSS_SCORE: 0.7171

HELIX: 0.0143

FCONS_SCORE: 1.0433

RIG_SCORE: 0.5867

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A545V	TCGA-AP-A1DK	UCEC	TCGA	PTTPEPS	DEG_SCF_FBW7_1	0.1389
p.K522Q	TCGA-AP-A1DV	UCEC	TCGA	PTTPEPS	DEG_SCF_FBW7_1	0.1667
p.D548N	TCGA-B5-A3FA	UCEC	TCGA	PTTPEPS	DEG_SCF_FBW7_1	0.0556
p.T534A	TCGA-CG-5728	STAD	TCGA	PTTPEPS	DEG_SCF_FBW7_1	0.825
p.K524N	TCGA-E6-A1LX	UCEC	TCGA	PTTPEPS	DEG_SCF_FBW7_1	0.2222
p.P542L	TCGA-W3-AA1V	SKCM	TCGA	PTTPEPS	DEG_SCF_FBW7_1	0.2222
p.E530D	DO9346	COAD	ICGC	PTTPEPS	DEG_SCF_FBW7_1	0.2778
p.E530D	DO234402	ESAD	ICGC	PTTPEPS	DEG_SCF_FBW7_1	0.2778
p.E530D	DO233230	GACA	ICGC	PTTPEPS	DEG_SCF_FBW7_1	0.2778
p.E530D	DO233291	GACA	ICGC	PTTPEPS	DEG_SCF_FBW7_1	0.2778
p.E530D	DO51799	STAD	ICGC	PTTPEPS	DEG_SCF_FBW7_1	0.2778
p.S538Y	DO7783	COAD	ICGC	PTTPEPS	DEG_SCF_FBW7_1	0.712
p.S538Y	DO26775	LUSC	ICGC	PTTPEPS	DEG_SCF_FBW7_1	0.712
p.S538Y	DO41584	UCEC	ICGC	PTTPEPS	DEG_SCF_FBW7_1	0.712
p.R532H	DO7862	COAD	ICGC	PTTPEPS	DEG_SCF_FBW7_1	0.8244
p.R532H	DO51545	PACA	ICGC	PTTPEPS	DEG_SCF_FBW7_1	0.8244
p.L544R	DO26455	LUSC	ICGC	PTTPEPS	DEG_SCF_FBW7_1	0.1667
p.S540L	DO27927	ORCA	ICGC	PTTPEPS	DEG_SCF_FBW7_1	0.2778
p.A528T	DO36317	PRAD	ICGC	PTTPEPS	DEG_SCF_FBW7_1	0.3333
p.R539H	DO36531	READ	ICGC	PTTPEPS	DEG_SCF_FBW7_1	0.3056
p.R539H	DO47940	STAD	ICGC	PTTPEPS	DEG_SCF_FBW7_1	0.3056
p.S522Y	DO43578	UCEC	ICGC	PTTPEPS	DEG_SCF_FBW7_1	0.1667
p.S522Y	DO43755	UCEC	ICGC	PTTPEPS	DEG_SCF_FBW7_1	0.1667
p.S522Y	DO41133	UCEC	ICGC	PTTPEPS	DEG_SCF_FBW7_1	0.1667
p.S522Y	DO43971	UCEC	ICGC	PTTPEPS	DEG_SCF_FBW7_1	0.1667
p.R547H	SIDM00953	Small Cell Lung Carcinoma	GDSC	PTTPEPS	DEG_SCF_FBW7_1	0.0833
p.A528P	ACH-000255	Gastric Cancer	CCLE	PTTPEPS	DEG_SCF_FBW7_1	0.3333
p.R539C	ACH-000823	Esophageal Cancer	CCLE	PTTPEPS	DEG_SCF_FBW7_1	0.3056
p.R539C	ACH-000994	Endometrial/Uterine Cancer	CCLE	PTTPEPS	DEG_SCF_FBW7_1	0.3056
p.R532C	ACH-000999	Colon/Colorectal Cancer	CCLE	PTTPEPS	DEG_SCF_FBW7_1	0.8301
p.S522F	ACH-002926	Unknown	CCLE	PTTPEPS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96M02		DEG_SCF_FBW7_1	532:538	PTTPEPS	FBXW7	0.6425	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTTPEPS

Degron related mutations and impact score

Drug responses associated with C10orf90 mutations

All proteins holding degron of PTTPEPS