DegronMD - Q96M11(HYLS1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S146Y	TCGA-A5-A0G2	UCEC	TCGA	LRQRLMNVQ	DEG_APCC_DBOX_1	131:139	Mutation rewiring degron network	0.1389
p.S146Y	DO41235	UCEC	ICGC	LRQRLMNVQ	DEG_APCC_DBOX_1	131:139	Mutation rewiring degron network	0.1389
p.D130E	TCGA-BR-8680	STAD	TCGA	LRQRLMNVQ	DEG_APCC_DBOX_1	131:139	Mutation rewiring degron network	0.3056
p.D130E	DO47769	STAD	ICGC	LRQRLMNVQ	DEG_APCC_DBOX_1	131:139	Mutation rewiring degron network	0.3056
p.G121C	TCGA-D3-A3C8	SKCM	TCGA	LRQRLMNVQ	DEG_APCC_DBOX_1	131:139	Mutation rewiring degron network	0.0556
p.G121C	DO47636	SKCM	ICGC	LRQRLMNVQ	DEG_APCC_DBOX_1	131:139	Mutation rewiring degron network	0.0556
p.L128I	TCGA-EO-A22U	UCEC	TCGA	LRQRLMNVQ	DEG_APCC_DBOX_1	131:139	Mutation rewiring degron network	0.25
p.L128I	DO43755	UCEC	ICGC	LRQRLMNVQ	DEG_APCC_DBOX_1	131:139	Mutation rewiring degron network	0.25
p.L128F	TCGA-EY-A1GI	UCEC	TCGA	LRQRLMNVQ	DEG_APCC_DBOX_1	131:139	Mutation rewiring degron network	0.25
p.L128F	DO41211	UCEC	ICGC	LRQRLMNVQ	DEG_APCC_DBOX_1	131:139	Mutation rewiring degron network	0.25
p.D127N	TCGA-FI-A2D0	UCEC	TCGA	LRQRLMNVQ	DEG_APCC_DBOX_1	131:139	Mutation rewiring degron network	0.2222
p.D127N	DO43891	UCEC	ICGC	LRQRLMNVQ	DEG_APCC_DBOX_1	131:139	Mutation rewiring degron network	0.2222
p.F140S	DO222837	MELA	ICGC	LRQRLMNVQ	DEG_APCC_DBOX_1	131:139	Mutation rewiring degron network	0.3056
p.D143N	ACH-001113	Lung Cancer	CCLE	LRQRLMNVQ	DEG_APCC_DBOX_1	131:139	Mutation rewiring degron network	0.2222
p.D143N	ACH-002156	Lung Cancer	CCLE	LRQRLMNVQ	DEG_APCC_DBOX_1	131:139	Mutation rewiring degron network	0.2222
p.D143N	LC-1-sq	lung	COSMIC	LRQRLMNVQ	DEG_APCC_DBOX_1	131:139	Mutation rewiring degron network	0.2222

Kaplan plot for HYLS1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HYLS1

UniProt ID: Q96M11

Entrez ID: 219844

Protein name: Hydrolethalus syndrome protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HYLS1 in