DegronMD

Uniprot ID: Q96M11

Source protein: Hydrolethalus syndrome protein 1

Source gene: HYLS1

Class: DEG_APCC_DBOX_1

Location: 131:139

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9507

ASA_SCORE: 95.1889

COIL: 0.3743

CONS_SCORE: 0.3718

DSS_SCORE: 0.3985

HELIX: 0.5973

FCONS_SCORE: 1.319

RIG_SCORE: 0.836

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S146Y	TCGA-A5-A0G2	UCEC	TCGA	LRQRLMNVQ	DEG_APCC_DBOX_1	0.1389
p.S146Y	DO41235	UCEC	ICGC	LRQRLMNVQ	DEG_APCC_DBOX_1	0.1389
p.D130E	TCGA-BR-8680	STAD	TCGA	LRQRLMNVQ	DEG_APCC_DBOX_1	0.3056
p.D130E	DO47769	STAD	ICGC	LRQRLMNVQ	DEG_APCC_DBOX_1	0.3056
p.G121C	TCGA-D3-A3C8	SKCM	TCGA	LRQRLMNVQ	DEG_APCC_DBOX_1	0.0556
p.G121C	DO47636	SKCM	ICGC	LRQRLMNVQ	DEG_APCC_DBOX_1	0.0556
p.L128I	TCGA-EO-A22U	UCEC	TCGA	LRQRLMNVQ	DEG_APCC_DBOX_1	0.25
p.L128I	DO43755	UCEC	ICGC	LRQRLMNVQ	DEG_APCC_DBOX_1	0.25
p.L128F	TCGA-EY-A1GI	UCEC	TCGA	LRQRLMNVQ	DEG_APCC_DBOX_1	0.25
p.L128F	DO41211	UCEC	ICGC	LRQRLMNVQ	DEG_APCC_DBOX_1	0.25
p.D127N	TCGA-FI-A2D0	UCEC	TCGA	LRQRLMNVQ	DEG_APCC_DBOX_1	0.2222
p.D127N	DO43891	UCEC	ICGC	LRQRLMNVQ	DEG_APCC_DBOX_1	0.2222
p.F140S	DO222837	MELA	ICGC	LRQRLMNVQ	DEG_APCC_DBOX_1	0.3056
p.D143N	ACH-001113	Lung Cancer	CCLE	LRQRLMNVQ	DEG_APCC_DBOX_1	0.2222
p.D143N	ACH-002156	Lung Cancer	CCLE	LRQRLMNVQ	DEG_APCC_DBOX_1	0.2222
p.D143N	LC-1-sq	lung	COSMIC	LRQRLMNVQ	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96M11	Hydrolethalus syndrome protein 1	DEG_APCC_DBOX_1	131:139	LRQRLMNVQ	APC,CDC20,FZR1	0.9507	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons