DegronMD - Q96MC5(BMERB1)

GO - Biological processes (BP): negative regulation of cell motility involved in cerebral cortex radial glia guided migration [GO:0021822]; negative regulation of microtubule depolymerization [GO:0007026]

GO - Molecular function (MF):

GO - Cellular component (CC): microtubule cytoskeleton [GO:0015630]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
LRIKLKPLD	DEG_APCC_DBOX_1	APC,CDC20,FZR1	bMERB domain-containing protein 1	152:160	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L159V	SIDM00057	Neuroblastoma	GDSC	LRIKLKPLD	DEG_APCC_DBOX_1	152:160	Mutation altering degron motif	0.5654
p.L159V	SIDM00552	Rhabdomyosarcoma	GDSC	LRIKLKPLD	DEG_APCC_DBOX_1	152:160	Mutation altering degron motif	0.5654
p.M148I	SIDM01394	Kidney Carcinoma	GDSC	LRIKLKPLD	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.2222
p.D145N	SIDM01387	Small Cell Lung Carcinoma	GDSC	LRIKLKPLD	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.1389

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No resistance data available for this Degron.

Kaplan plot for BMERB1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BMERB1

UniProt ID: Q96MC5

Entrez ID: 89927

Protein name: bMERB domain-containing protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for BMERB1 in