DegronMD

Uniprot ID: Q96MC5

Source protein: bMERB domain-containing protein 1

Source gene: BMERB1

Class: DEG_APCC_DBOX_1

Location: 152:160

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8007

ASA_SCORE: 102.1556

COIL: 0.5704

CONS_SCORE: 0.8201

DSS_SCORE: 0.4171

HELIX: 0.42

FCONS_SCORE: 1.092

RIG_SCORE: 0.7859

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L159V	SIDM00057	Neuroblastoma	GDSC	LRIKLKPLD	DEG_APCC_DBOX_1	0.5654
p.L159V	SIDM00552	Rhabdomyosarcoma	GDSC	LRIKLKPLD	DEG_APCC_DBOX_1	0.5654
p.M148I	SIDM01394	Kidney Carcinoma	GDSC	LRIKLKPLD	DEG_APCC_DBOX_1	0.2222
p.D145N	SIDM01387	Small Cell Lung Carcinoma	GDSC	LRIKLKPLD	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96MC5	bMERB domain-containing protein 1	DEG_APCC_DBOX_1	152:160	LRIKLKPLD	APC,CDC20,FZR1	0.8007	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons