DegronMD - Q96MP5(ZSWIM3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.C561Y	TCGA-37-4133	LUSC	TCGA	CRHILALLH	DEG_APCC_DBOX_1	561:569	Mutation altering degron motif	0.5976
p.R562Q	TCGA-B5-A0K9	UCEC	TCGA	CRHILALLH	DEG_APCC_DBOX_1	561:569	Mutation altering degron motif	0.7329
p.Q554E	TCGA-VS-A9U6	CESC	TCGA	CRHILALLH	DEG_APCC_DBOX_1	561:569	Mutation rewiring degron network	0.1389
p.C575Y	DO219759	CESC	ICGC	CRHILALLH	DEG_APCC_DBOX_1	561:569	Mutation rewiring degron network	0.1667
p.M573I	DO230309	COCA	ICGC	CRHILALLH	DEG_APCC_DBOX_1	561:569	Mutation rewiring degron network	0.2222
p.R576S	DO233639	GACA	ICGC	CRHILALLH	DEG_APCC_DBOX_1	561:569	Mutation rewiring degron network	0.1389
p.W578L	DO229029	LICA	ICGC	CRHILALLH	DEG_APCC_DBOX_1	561:569	Mutation rewiring degron network	0.0833
p.L559V	DO23410	LINC	ICGC	CRHILALLH	DEG_APCC_DBOX_1	561:569	Mutation rewiring degron network	0.2778
p.C555Y	DO26465	LUSC	ICGC	CRHILALLH	DEG_APCC_DBOX_1	561:569	Mutation rewiring degron network	0.1667
p.R577W	DO219153	LUSC	ICGC	CRHILALLH	DEG_APCC_DBOX_1	561:569	Mutation rewiring degron network	0.1111
p.R556Q	DO42097	UCEC	ICGC	CRHILALLH	DEG_APCC_DBOX_1	561:569	Mutation rewiring degron network	0.1944
p.G576D	SIDM00985	Burkitt's Lymphoma	GDSC	CRHILALLH	DEG_APCC_DBOX_1	561:569	Mutation rewiring degron network	0.1389
p.G576D	ACH-000245	Lymphoma	CCLE	CRHILALLH	DEG_APCC_DBOX_1	561:569	Mutation rewiring degron network	0.1389
p.G576D	BL-41	haematopoietic and lymphoid tissue	COSMIC	CRHILALLH	DEG_APCC_DBOX_1	561:569	Mutation rewiring degron network	0.1389
p.C551F	SIDM00153	T-Lymphoblastic Leukemia	GDSC	CRHILALLH	DEG_APCC_DBOX_1	561:569	Mutation rewiring degron network	0.0556
p.C551F	ACH-000964	Leukemia	CCLE	CRHILALLH	DEG_APCC_DBOX_1	561:569	Mutation rewiring degron network	0.0556

Kaplan plot for ZSWIM3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZSWIM3

UniProt ID: Q96MP5

Entrez ID: 140831

Protein name: Zinc finger SWIM domain-containing protein 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZSWIM3 in