DegronMD

Uniprot ID: Q96MP5

Source protein: Zinc finger SWIM domain-containing protein 3

Source gene: ZSWIM3

Class: DEG_APCC_DBOX_1

Location: 561:569

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6497

ASA_SCORE: 28.8444

COIL: 0.0377

CONS_SCORE: 0.5933

DSS_SCORE: 0.0421

HELIX: 0.9534

FCONS_SCORE: 1.2047

RIG_SCORE: 0.8782

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C561Y	TCGA-37-4133	LUSC	TCGA	CRHILALLH	DEG_APCC_DBOX_1	0.5976
p.R562Q	TCGA-B5-A0K9	UCEC	TCGA	CRHILALLH	DEG_APCC_DBOX_1	0.7329
p.Q554E	TCGA-VS-A9U6	CESC	TCGA	CRHILALLH	DEG_APCC_DBOX_1	0.1389
p.C575Y	DO219759	CESC	ICGC	CRHILALLH	DEG_APCC_DBOX_1	0.1667
p.M573I	DO230309	COCA	ICGC	CRHILALLH	DEG_APCC_DBOX_1	0.2222
p.R576S	DO233639	GACA	ICGC	CRHILALLH	DEG_APCC_DBOX_1	0.1389
p.W578L	DO229029	LICA	ICGC	CRHILALLH	DEG_APCC_DBOX_1	0.0833
p.L559V	DO23410	LINC	ICGC	CRHILALLH	DEG_APCC_DBOX_1	0.2778
p.C555Y	DO26465	LUSC	ICGC	CRHILALLH	DEG_APCC_DBOX_1	0.1667
p.R577W	DO219153	LUSC	ICGC	CRHILALLH	DEG_APCC_DBOX_1	0.1111
p.R556Q	DO42097	UCEC	ICGC	CRHILALLH	DEG_APCC_DBOX_1	0.1944
p.G576D	SIDM00985	Burkitt's Lymphoma	GDSC	CRHILALLH	DEG_APCC_DBOX_1	0.1389
p.G576D	ACH-000245	Lymphoma	CCLE	CRHILALLH	DEG_APCC_DBOX_1	0.1389
p.G576D	BL-41	haematopoietic_and_lymphoid_tissue	COSMIC	CRHILALLH	DEG_APCC_DBOX_1	0.1389
p.C551F	SIDM00153	T-Lymphoblastic Leukemia	GDSC	CRHILALLH	DEG_APCC_DBOX_1	0.0556
p.C551F	ACH-000964	Leukemia	CCLE	CRHILALLH	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96MP5	Zinc finger SWIM domain-containing protein 3	DEG_APCC_DBOX_1	561:569	CRHILALLH	APC,CDC20,FZR1	0.6497	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons