DegronMD - Q96MW1(CCDC43)

GO - Biological processes (BP):

GO - Molecular function (MF):

GO - Cellular component (CC): cytosol [GO:0005829]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
DSGATT	DEG_SCF_TRCP1_1	BTRC	Coiled-coil domain-containing protein 43	150:155	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E147D	TCGA-BA-4077	HNSC	TCGA	DSGATT	DEG_SCF_TRCP1_1	150:155	Mutation rewiring degron network	0.25
p.E147D	DO15647	HNSC	ICGC	DSGATT	DEG_SCF_TRCP1_1	150:155	Mutation rewiring degron network	0.25
p.P146L	RPMI-8226	haematopoietic and lymphoid tissue	COSMIC	DSGATT	DEG_SCF_TRCP1_1	150:155	Mutation rewiring degron network	0.2222
p.A145S	TCGA-A5-A1OF	UCEC	TCGA	DSGATT	DEG_SCF_TRCP1_1	150:155	Mutation rewiring degron network	0.1944
p.A145S	DO42568	UCEC	ICGC	DSGATT	DEG_SCF_TRCP1_1	150:155	Mutation rewiring degron network	0.1944
p.L163I	DO229045	LICA	ICGC	DSGATT	DEG_SCF_TRCP1_1	150:155	Mutation rewiring degron network	0.1111
p.L163F	SIDM01039	Other Solid Cancers	GDSC	DSGATT	DEG_SCF_TRCP1_1	150:155	Mutation rewiring degron network	0.1111

Showing 1 to 7 of 7 entries

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons