DegronMD

Uniprot ID: Q96MW1

Source protein: Coiled-coil domain-containing protein 43

Source gene: CCDC43

Class: DEG_SCF_TRCP1_1

Location: 150:155

E3 ligase: BTRC

DEGRON score: 0.9892

ASA_SCORE: 77.7667

COIL: 0.8328

CONS_SCORE: 0.4241

DSS_SCORE: 0.5867

HELIX: 0.0893

FCONS_SCORE: 0.7749

RIG_SCORE: 0.686

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A145S	TCGA-A5-A1OF	UCEC	TCGA	DSGATT	DEG_SCF_TRCP1_1	0.1944
p.A145S	DO42568	UCEC	ICGC	DSGATT	DEG_SCF_TRCP1_1	0.1944
p.E147D	TCGA-BA-4077	HNSC	TCGA	DSGATT	DEG_SCF_TRCP1_1	0.25
p.E147D	DO15647	HNSC	ICGC	DSGATT	DEG_SCF_TRCP1_1	0.25
p.L163I	DO229045	LICA	ICGC	DSGATT	DEG_SCF_TRCP1_1	0.1111
p.L163F	SIDM01039	Other Solid Cancers	GDSC	DSGATT	DEG_SCF_TRCP1_1	0.1111
p.P146L	RPMI-8226	haematopoietic_and_lymphoid_tissue	COSMIC	DSGATT	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96MW1	Coiled-coil domain-containing protein 43	DEG_SCF_TRCP1_1	150:155	DSGATT	BTRC	0.9892	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons